Evidence map›Paper›PMID 31296937›Full record

ArticleNature2019

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.

Marco De Cecco, Takahiro Ito, Anna P Petrashen, Amy E Elias, Nicholas J Skvir, Steven W Criscione, Alberto Caligiana, Greta Brocculi, Emily M Adney, Jef D Boeke and 11 more

Open access · bronzeAbstract readPublished Erratum
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. LINE-1 retrotransposon activation drives age-associated inflammationContemporary oncology (Poznan, Poland) · 2025
    Review
  4. Article
  5. Article
  6. Loss of H3K9 trimethylation leads to premature aging.bioRxiv : the preprint server for biology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Transposable Elements Co-Option in Genome Evolution and Gene Regulation.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Article
  13. Healthy Aging Interventions Reduce Repetitive Element Transcripts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  14. Article
  15. Senolytic drugs: from discovery to translation.Journal of internal medicine · 2020
    Review
  16. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 4 countries.

Marco De CeccoDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Takahiro ItoDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Anna P PetrashenDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Amy E EliasDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Nicholas J SkvirDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Steven W CriscioneDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Alberto CaligianaDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Greta BrocculiDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Emily M AdneyInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Oanh LeCentre de Recherche CHU Ste-Justine, and Department of Pharmacology and Physiology, Université de Montréal, Montréal, Québec, Canada.
Christian BeauséjourCentre de Recherche CHU Ste-Justine, and Department of Pharmacology and Physiology, Université de Montréal, Montréal, Québec, Canada.
Jayakrishna AmbatiCenter for Advanced Vision Science and Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Kameshwari AmbatiCenter for Advanced Vision Science and Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Matthew SimonDepartment of Biology, University of Rochester, Rochester, NY, USA.
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY, USA.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, USA.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
Stephen L HelfandDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
Nicola NerettiDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA.
John M SedivyDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, USA. john_sedivy@brown.edu.
Brown University · USUniversity of Rochester · USUniversité de Montréal · CAUniversity of Virginia · USInstitute for Systems Biology · USJohns Hopkins Medicine · USLeiden University Medical Center · NL

Funding

The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9M
Somatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4M
The role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2M
MECHANISMS OF REPLICATIVE SENESCENCE IN CELLSR01AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 1999 to 2024
$5.7M
Effectors of cellular senescence statesR37AG016694 · NIA · BROWN UNIVERSITY · PI SEDIVY, JOHN M · 2009 to 2018
$3.2M
NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG016694NIA NIH HHS R01 AG027237NIA NIH HHS R37 AG016694
6 · The paper itself

Abstract

An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

Identifiers

PMID31296937
PMCPMC7017651
OpenAlexW2959311507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.