Trial reportEuropean journal of clinical nutrition2020
Anaemia and iron deficiency in pregnancy and adverse perinatal outcomes in Southern India.
Trial report in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Impact of maternal micronutrient supplementation on pregnancy outcomes in developing countries: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- The effect of maternal anemia during pregnancy on low birth weight in Ethiopia; a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- The Effect of Maternal Haemoglobinopathies and Iron Deficiency Anaemia on Foetal Growth Restriction: A Systematic Review and Meta-Analysis.Maternal & child nutrition · 2025Pooled it
- Prevalence of anemia in India: a systematic review, meta-analysis and geospatial analysis.BMC public health · 2025Pooled it
- Vitamin B12 supplementation during pregnancy for maternal and child health outcomes.The Cochrane database of systematic reviews · 2024Pooled it
- Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis.BMC pregnancy and childbirth · 2023Pooled it
- Anemia and adverse outcomes in pregnancy: subgroup analysis of the CLIP cluster-randomized trial in India.BMC pregnancy and childbirth · 2022Trial
- Risk of stillbirth among pregnant women with anaemia in India: secondary analysis of multiple cohorts from the ICMR-SPIC consortium.The Lancet regional health. Southeast Asia · 2026Article
- Relationship of the Soluble Transferrin Receptor-Ferritin (sTfR-Ferritin) Index with Adverse Pregnancy Outcomes.Biological trace element research · 2026Article
- Iron deficiency with and without anemia in pregnancy: A scoping review of prevalence and perinatal impact.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- A silent link between stillbirth and maternal anaemia: evidence from the fifth round of the National Family Health Survey.Reproductive health · 2026Article
- Neonatal outcomes following maternal red cell transfusions prior to or at delivery.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Maternal mineral nutrition during early pregnancy and neonatal growth: findings from a China birth cohort study.Frontiers in nutrition · 2026Article
- Comparison of methods for in vivo and ex vivo quantification of iron in murine brain tumors.PloS one · 2026Article
- Global, regional and national disease burden of neonatal disorders from 2000 to 2021 and the comparison before and during COVID-19: a systematic analysis.BMC public health · 2025Article
- Cohort profile: the Maharashtra Anaemia Study 3 (MAS 3)-a maternal-child cohort study up to age 18 years in India.BMJ open · 2025Article
- Iron as a Modifiable Factor for Adverse Pregnancy Outcomes: Refining and Understanding Causal Estimates Using Mendelian Randomization.Biological trace element research · 2025Article
- The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.BMC public health · 2025Article
- Serum ferritin levels and risk of gestational diabetes mellitus: A cohort study.Scientific reports · 2025Article
- "I believe it when there is an expert next to me:" a qualitative analysis on the perceptions and experiences of pregnant women to self-monitor blood pressure in Lombok, Indonesia.BMC pregnancy and childbirth · 2025Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesWe examined the prevalence of anaemia, iron deficiency, and inflammation during pregnancy and their associations with adverse pregnancy and infant outcomes in India. SUBJECTS/
methodsThree hundred and sixty-six women participating in a randomised trial of vitamin B
resultsThirty percent of women were anaemic (Hb < 11.0 g/dl), 48% were iron deficient (SF < 15.0 µg/l), and 23% had iron deficiency anaemia at their first prenatal visit. The prevalence of inflammation (CRP > 5.0 mg/l: 17%; AGP > 1.0 g/l: 11%) and anaemia of inflammation (Hb < 11.0 g/dl, SF > 15.0 µg/l, plus CRP > 5.0 mg/l or AGP > 1.0 g/l: 2%) were low. Infants born to anaemic women had a twofold higher risk of low birth weight (<2500 g; risk ratio [RR]: 2.15, 95%CI: 1.20-3.84, p = 0.01), preterm delivery (RR: 2.67 (1.43-5.00); p = 0.002), underweight (WAZ < -2; RR: 2.20, 95%CI: 1.16-4.15, p = 0.02), and lower MUAC (β(SE): -0.94 (0.45)cm, p = 0.03). Similarly, maternal Hb concentrations predicted higher infant birth weight (p = 0.02) and greater gestational age at delivery (β(SE): 0.28 (0.08) weeks, p = 0.001), lower risk of preterm delivery (<37 weeks; RR: 0.76, 95%CI: 0.66-86, p < 0.0001); and higher infant MUAC (β(SE): 0.36 (0.13) cm, p = 0.006). Maternal SF concentrations were associated with greater birth length (β(SE): 0.44 (0.20) cm, p < 0.03). Findings were similar after adjusting SF concentrations for inflammation. IDA was associated with higher risk of low birth weight (RR: 1.99 (1.08-3.68); p = 0.03) and preterm birth (RR: 3.46 (1.81-6.61); p = 0.0002); and lower birth weight (p = 0.02), gestational age at birth (p = 0.0002), and infant WAZ scores (p = 0.02).
conclusionsThe prevalence of anaemia and iron deficiency was high early in pregnancy and associated with increased risk of adverse pregnancy and infant outcomes. A comprehensive approach to prevent anaemia is needed in women of reproductive age, to enhance haematological status and improve maternal and child health outcomes.
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