Evidence map›Paper›PMID 31296918›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2019

Inadequate oral feeding as a barrier to discharge in moderately preterm infants.

Laura Edwards, C Michael Cotten, P Brian Smith, Ronald Goldberg, Shampa Saha, Abhik Das, Abbot R Laptook, Barbara J Stoll, Edward F Bell, Waldemar A Carlo and 9 more

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06736743 completednot on this mapstarted 2025, after this paper: background citation

Review of Infant Oral Feeding and Skills Study

TypeobservationalSponsorWake Forest University Health SciencesRan2025 to 2026Enrolled108ConditionsNutrition Disorders, Gastrointestinal Disease, Deglutition Disorder, Feeding DifficultiesArmsSMART Tool for Feeding Skill Assessment
NCT07136610 narecruitingnot on this mapstarted 2025, after this paper: background citation

Standardized Application of Feeding Evaluations Using SMART Tool

TypeinterventionalSponsorWake Forest University Health SciencesRan2025 to 2027Enrolled3,500ConditionsInfant and Young Child FeedingArmsSMART Tool
3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. We're going bananas! The effectiveness and safety of banana puree as an intervention for improving oral feeding in a level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  2. One-year outcomes of infants discharged with a nasogastric feeding tube.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Article
  4. Observational
  5. Article
  6. Effects of a remote patient monitoring program on cost of care for neonates with inadequate oral feeding.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  7. Demographic and clinical predictors and inter-center variability of tube feeding in preterm NICU patients.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Oral stimulation for promoting oral feeding in preterm infants.The Cochrane database of systematic reviews · 2023
    Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Laura EdwardsDepartment of Pediatrics, Duke University, Durham, NC, 27708, USA.
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC, 27708, USA.
P Brian SmithDepartment of Pediatrics, Duke University, Durham, NC, 27708, USA.
Ronald GoldbergDepartment of Pediatrics, Duke University, Durham, NC, 27708, USA.
Shampa SahaSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC, 27709, United States.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, 27709, USA.
Abbot R LaptookDepartment of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, 02912, USA.
Barbara J StollDepartment of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, IA, 52242, USA.ORCID http://orcid.org/0000-0002-5568-0889
Waldemar A CarloDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Carl T D'AngioUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Sara B DeMauroDepartment of Pediatrics, The Children's Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA, 19104, USA.
Pablo J SanchezDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, OH, 43205, USA.
Seetha ShankaranDepartment of Pediatrics, Wayne State University, Detroit, MI, 48202, USA.
Krisa P Van MeursDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Lucile Packard Children's Hospital, Stanford University School of Medicine, Palo Alto, CA, 94305, USA.
Betty R VohrDepartment of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, 02912, USA.
Michele C WalshDepartment of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, 44106, USA.
William F MalcolmDepartment of Pediatrics, Duke University, Durham, NC, 27708, USA. william.malcolm@duke.edu.
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Zosuquidar trihydrochloride for acute myeloid leukemia &refractory anemiaM01RR000080 · NCRR · UNIVERSITY HOSPITALS OF CLEVELAND · PI DEARBORN, DORR GELLATLY · 1985 to 2007
$22.2M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9M
NCATS NIH HHS UL1 TR000006NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000442NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1 TR001449NCATS NIH HHS UL1 TR002489NCATS NIH HHS UL1 TR003142NCRR NIH HHS M01 RR000080NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053089NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD068244NICHD NIH HHS U10 HD068263NICHD NIH HHS U10 HD068270NICHD NIH HHS U10 HD068278NICHD NIH HHS U10 HD068284NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270
6 · The paper itself

Abstract

objectivesThe objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities. STUDY

designProspective study using the NICHD Neonatal Research Network MPT Registry. Multivariable logistic regression was used to describe associations between IOF and continued hospitalization at 36 weeks postmenstrual age (PMA).

resultA total of 6017 MPT infants from 18 centers were included. Three-thousand three-seventy-six (56%) remained hospitalized at 36 weeks PMA, of whom 1262 (37%) remained hospitalized due to IOF. IOF was associated with RDS (OR 2.02, 1.66-2.46), PDA (OR 1.86, 1.37-2.52), sepsis (OR 2.36, 95% 1.48-3.78), NEC (OR 16.14, 7.27-35.90), and BPD (OR 3.65, 2.56-5.21) compared to infants discharged and was associated with medical NEC (OR 2.06, 1.19-3.56) and BPD (OR 0.46, 0.34-0.61) compared to infants remaining hospitalized for an alternative reason.

conclusionIOF is the most common barrier to discharge in MPT infants, especially among those with neonatal morbidities.

Indexed as

Energy IntakeFeeding BehaviorInfant, PrematurePatient DischargeBottle FeedingBreast FeedingFeeding MethodsFemaleHumansInfantInfant, NewbornLogistic ModelsMaleProspective StudiesRespiratory Distress Syndrome, NewbornSepsis

Identifiers

PMID31296918
PMCPMC7246972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.