ArticleScientific reports2019
Population density and water balance influence the global occurrence of hepatitis E epidemics.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Acute hepatitis E in older adults: global trends from the global burden of disease study.Virology journal · 2026Article
- Shellfish as a Potential Source of Hepatitis E Virus: Epidemiological Evidence, Biological Plausibility, and Research Gaps.Viruses · 2026Review
- Global distribution and health impact of infectious disease outbreaks, 1996-2023: a worldwide retrospective analysis of World Health Organization emergency event reports.Journal of global health · 2025Article
- Meteorological determinants of hepatitis E dynamics in Jiangsu Province, China: a pre-COVID-19 era study focusing on multi-route transmission (2005-2018).Frontiers in public health · 2025Article
- From discovery to treatment: tracing the path of hepatitis E virus.Virology journal · 2024Review
- Spatio-temporal pattern and associate factors of intestinal infectious diseases in Zhejiang Province, China, 2008-2021: a Bayesian modeling study.BMC public health · 2023Article
- Analysis of seroprevalence and risk factors for hepatitis E virus (HEV) in donation candidates and blood donors in Northeast Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- In silico study on the Hepatitis E virus RNA Helicase and its inhibition by silvestrol, rocaglamide and other flavagline compounds.Scientific reports · 2022Article
- Epidemiological Profile of a Human Hepatitis E Virus Outbreak in 2018, Chattogram, Bangladesh.Tropical medicine and infectious disease · 2022Article
- Hepatitis E virus in pigs and the environment: An updated review of public health concerns.Narra J · 2022Review
- Prospect of acute hepatitis E virus outbreak in the context of the COVID-19 Pandemic in Africa: A contingency plan.Annals of medicine and surgery (2012) · 2022Article
- Prevalence of Viral Hepatitis B, C, and D in Kazakhstan.TheScientificWorldJournal · 2022Article
- Hepatitis E in Sub Saharan Africa - A significant emerging disease.One health (Amsterdam, Netherlands) · 2021Review
- Towards the Improved Accuracy of Hepatitis E Diagnosis in Vulnerable and Target Groups: A Global Perspective on the Current State of Knowledge and the Implications for Practice.Healthcare (Basel, Switzerland) · 2021Review
- Role of Hepatitis E Virus Infection in North American Patients With Severe Acute Liver Injury.Clinical and translational gastroenterology · 2020Observational
- Hepatitis E Virus Infection: Circulation, Molecular Epidemiology, and Impact on Global Health.Pathogens (Basel, Switzerland) · 2020Review
- Hepatitis E virus outbreak associated with rainfall in the Central African Republic in 2008-2009.BMC infectious diseases · 2020Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In developing countries, the waterborne transmission of hepatitis E virus (HEV), caused by HEV genotypes 1 (HEV-1) and 2 (HEV-2), leads to the onset of large recurrent outbreaks. HEV infections are of particular concern among pregnant women, due to very high mortality rates (up to 70%). Unfortunately, good understanding of the factors that trigger the occurrence of HEV epidemics is currently lacking; therefore, anticipating the onset of an outbreak is yet not possible. In order to map the geographical regions at higher risk of HEV epidemics and the conditions most favorable for the transmission of the virus, we compiled a dataset of HEV waterborne outbreaks and used it to obtain models of geographical suitability for HEV across the planet. The main three variables that best predict the geographical distribution of HEV outbreaks at global scale are population density, annual potential evapotranspiration and precipitation seasonality. At a regional scale, the temporal occurrence of HEV outbreaks in the Ganges watershed is negatively correlated with the discharge of the river (r = -0.77). Combined, our findings suggest that ultimately, population density and water balance are main parameters influencing the occurrence of HEV-1 and HEV-2 outbreaks. This study expands the current understanding of the combination of factors shaping the biogeography and seasonality of waterborne viral pathogens such as HEV-1 and HEV-2, and contributes to developing novel concepts for the prediction and control of human waterborne viruses in the near future.
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