ArticleNature communications2019
Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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31 citing papers in PubMed, 52 citations in OpenAlex.
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- Genomic and phenotypic adaptations of methicillin resistant Staphylococcus aureus during vancomycin therapy.Scientific reports · 2025Article
- Thermal shift assay to identify ligands for bacterial sensor proteins.FEMS microbiology reviews · 2025Review
- The anti-biofilm compound 4-ethoxybenzoic acid inhibitsFrontiers in microbiology · 2025Article
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- Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis.Annual review of microbiology · 2024Review
- Microbiota and metabolic adaptation shapebioRxiv : the preprint server for biology · 2024Article
- Crosstalk involving two-component systems inJournal of bacteriology · 2024Review
- Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.Science advances · 2023Article
- Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems.Biochemistry · 2023Review
- Bacterial Two Component Systems: Overexpression and Purification: In Vitro and In Vivo Inhibitor Screens.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Familial ALS-associatedOpen biology · 2022Article
- Article
- The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation inFrontiers in microbiology · 2022Article
- Two-Component Systems ofGenes · 2021Review
- The Role ofAntibiotics (Basel, Switzerland) · 2021Review
- Diversity in Sensing and Signaling of Bacterial Sensor Histidine Kinases.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Ian R MonkDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia. ian.monk@unimelb.edu.au.
Nausad ShaikhInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.
Stephanie L BeggDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.
Mike GajdissUniversity Clinics of Bonn, Institute of Medical Microbiology, Immunology and Parasitology, 53127, Bonn, Germany.
Liam K R SharkeyDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0001-9324-8678
Jean Y H LeeDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0001-5751-8503
Sacha J PidotDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0003-1202-6614
Torsten SeemannDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0001-6046-610X
Michael KuiperCSIRO Data61, Canberra, ACT, 2601, Australia.
Brit Winnen
Rikki HvorupInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.
Brett M CollinsInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.
Gabriele BierbaumUniversity Clinics of Bonn, Institute of Medical Microbiology, Immunology and Parasitology, 53127, Bonn, Germany.
Saumya R UdagedaraDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.
Jacqueline R MoreyDepartment of Molecular and Biomedical Sciences, School of Biological Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.ORCID http://orcid.org/0000-0003-4544-5997
Neha PulyaniDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.
Benjamin P HowdenDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0003-0237-1473
Megan J MaherDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia.ORCID http://orcid.org/0000-0003-0848-9640
Christopher A McDevittDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia.ORCID http://orcid.org/0000-0003-1596-4841
Glenn F KingInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.
Timothy P StinearDepartment of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, 3000, Australia. tstinear@unimelb.edu.au.ORCID http://orcid.org/0000-0003-0150-123X
The University of Melbourne · AUThe University of Queensland · AULa Trobe University · AUCommonwealth Scientific and Industrial Research Organisation · AUThe University of Adelaide · AU
Funding
Department of Education and Training | Australian Research Council (ARC) DP170102102Department of Education and Training | Australian Research Council (ARC) FT170100006Department of Health | National Health and Medical Research Council (NHMRC) GNT1010776Department of Health | National Health and Medical Research Council (NHMRC) GNT1044414Department of Health | National Health and Medical Research Council (NHMRC) GNT1049192Department of Health | National Health and Medical Research Council (NHMRC) GNT1105525Department of Health | National Health and Medical Research Council (NHMRC) GNT1105905Department of Health | National Health and Medical Research Council (NHMRC) GNT1129589Department of Health | National Health and Medical Research Council (NHMRC) GNT1136021Department of Health | National Health and Medical Research Council (NHMRC) GNT1142695Department of Health | National Health and Medical Research Council (NHMRC) GNT1145075
Abstract
WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does not explain its essentiality. Here, to further understand WalKR function, we investigate a suppressor mutant that arose when WalKR activity was impaired; a histidine to tyrosine substitution (H271Y) in the cytoplasmic Per-Arnt-Sim (PAS
Indexed as
Amino Acid SubstitutionBacterial ProteinsCations, DivalentHistidineHistidine KinaseMolecular Dynamics SimulationMutationProtein Serine-Threonine KinasesRegulonStaphylococcus aureusTyrosineZincBacterial ProteinsCations, DivalentHistidineHistidine KinasePAS domain kinasesProtein Serine-Threonine KinasesTyrosineYycF protein, BacteriaZinc
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.