ArticleNature communications2019
Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 112 citations in OpenAlex.
- Photothermal catalysis versus thermal catalysis: A palladium-catalyzed intermolecular three-component C─H 1,3-Science advances · 2026Article
- Recent advances in organocatalytic atroposelective reactions.Beilstein journal of organic chemistry · 2025Review
- Atroposelective catalysis.Nature reviews. Chemistry · 2024Review
- Recent Advances in π-Stacking Interaction-Controlled Asymmetric Synthesis.Molecules (Basel, Switzerland) · 2024Review
- Synthesis of axially chiral diaryl ethersChemical science · 2024Article
- Organocatalytic enantioselective synthesis of CChemical science · 2024Article
- Atroposelective Synthesis of Aldehydes via Alcohol Dehydrogenase-Catalyzed Stereodivergent Desymmetrization.JACS Au · 2024Article
- Cooperative Cu/azodiformate system-catalyzed allylic C-H amination of unactivated internal alkenes directed by aminoquinoline.Nature communications · 2024Article
- Axially chiral styrene-based organocatalysts and their application in asymmetric cascade Michael/cyclization reaction.Chemical science · 2023Article
- Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality.Molecules (Basel, Switzerland) · 2023Review
- Advances in the Asymmetric Synthesis of BINOL Derivatives.Molecules (Basel, Switzerland) · 2022Review
- Rhodium-Catalyzed [2 + 2 + 2] Cyclotrimerizations of Yndiamides with Alkynes.Organic letters · 2022Article
- Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C-N Axis via Enantioselective Catalysis.Molecules (Basel, Switzerland) · 2022Review
- Asymmetric Synthesis of Axially Chiral C-N Atropisomers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Review
- Atropoenantioselective palladaelectro-catalyzed anilide C-H olefinations viable with natural sunlight as sustainable power source.Chemical science · 2022Article
- Enantioselective Aromatic Amination?Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Recent advances in the asymmetric phosphoric acid-catalyzed synthesis of axially chiral compounds.Beilstein journal of organic chemistry · 2021Review
- Asymmetric allylic substitution-isomerization to axially chiral enamidesChemical science · 2020Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Nonbiaryl N-C atropisomer is an important structural scaffold, which is present in natural products, medicines and chiral ligands. However the direct enantioselective C-H amination to access optically pure N-C atropisomer is still difficult and rare. Here we report a π-π interaction and dual H-bond concerted control strategy to develop the chiral phosphoric acids (CPAs) catalyzed direct intermolecular enantioselective C-H amination of N-aryl-2-naphthylamines with azodicarboxylates as amino sources for the construction of atroposelective naphthalene-1,2-diamines. This type of N-C atropisomers is stabilized by intramolecular hydrogen bond and the method features a broad range of substrates, high yields and ee values, providing a strategy to chirality transfer via the modification of N-C atropisomers.
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Registered trials
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