Evidence map›Paper›PMID 31296772›Full record

ArticleScience (New York, N.Y.)2019

Protein interaction networks revealed by proteome coevolution.

Qian Cong, Ivan Anishchenko, Sergey Ovchinnikov, David Baker

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 272 citations in OpenAlex.

  1. Two D-loop resolution systems enable natural genetic transformation in bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Linear-time prediction of proteome-scale microbial protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Predicting Protein-Protein Interactions from Machine-Learned Representations.Advances in experimental medicine and biology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Recent progress and future challenges in structure-based protein-protein interaction prediction.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  15. Article
  16. Article
  17. Crowding and in-Cell Crystallization.Sub-cellular biochemistry · 2025
    Review
  18. Article
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Qian CongDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-8909-0414
Ivan AnishchenkoDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0003-3645-2044
Sergey OvchinnikovJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA 02138, USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
University of Washington · USHarvard University Press · USHoward Hughes Medical Institute · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
High resolution structure modeling with RosettaR01GM092802 · NIGMS · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2010 to 2017
$2.3M
Exploring the unknown protein universe using evolutionary informationDP5OD026389 · OD · HARVARD UNIVERSITY · PI OVCHINNIKOV, SERGEY L. · 2018 to 2022
$2.0M
Howard Hughes Medical InstituteNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS R01 GM092802NIGMS NIH HHS T32 GM007270NIH HHS DP5 OD026389
6 · The paper itself

Abstract

Residue-residue coevolution has been observed across a number of protein-protein interfaces, but the extent of residue coevolution between protein families on the whole-proteome scale has not been systematically studied. We investigate coevolution between 5.4 million pairs of proteins in

Indexed as

Biological CoevolutionProtein Interaction MapsBacterial ProteinsEscherichia coliEscherichia coli ProteinsMycobacterium tuberculosisProtein ConformationProteomeBacterial ProteinsEscherichia coli ProteinsProteome

Identifiers

PMID31296772
PMCPMC6948103
OpenAlexW2957157683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.