Evidence map›Paper›PMID 31296508›Full record

ArticleBMJ open2019

Efficacy of mindfulness-based intervention ('mindfulness-based joyful sleep') in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a prospective protocol of a randomised controlled trial in China.

Chen Pan, Xiang Wang, Yunlong Deng, Peihuan Li, Yanhui Liao, Xin Ma, Guo-Ping Yang, Lisha Dai, Qiuping Tang

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03268629 (The Efficacy of a Mindfulness-Based Intervention for Insomnia), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03268629 naunknown statusnot on this map

The Efficacy of a Mindfulness-Based Intervention for Insomnia ('Mindfulness-Based Joyful Sleep') in Young and Middle-aged Individuals With Insomnia in China: Study Protocol of a Randomized Controlled Trial

TypeinterventionalSponsorCentral South UniversityRan2018 to 2021Enrolled70ConditionsInsomniaArmsMindfulness-Based Joyful Sleep, CBT-I
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams.Computational and mathematical methods in medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chen PanDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiang WangDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yunlong DengPsychosomatic Health Institute, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peihuan LiDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanhui LiaoDepartment of Psychiatry and Mental Health Institute, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xin MaDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guo-Ping YangCenter of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lisha DaiDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qiuping TangDepartment of Clinical Psychology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0003-0676-6835
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsomnia is a prevalent and significant public health concern. Insomnia can lead to increased inflammatory markers associated with chronic diseases such as cardiovascular disease, diabetes and cancer. Studies suggest that mindfulness-based interventions (MBIs) are more easily delivered within the community than cognitive behavioural therapy for insomnia (CBT-I) which was recommended as the preferred non-pharmacological treatment by the American Academy of Sleep Medicine, are effective in insomnia treatment and can reduce inflammatory markers level in older individuals with insomnia. This study aims to compare the effectiveness of an MBI to CBT-I in young and middle-aged individuals with insomnia disorder and explore its effect on nuclear factor kappa B (NF-κB), a transcription factor that controls the expression of genes involved in inflammation. METHODS AND ANALYSIS: This report describes a protocol for a randomised controlled trial. Seventy eligible participants will be assigned to mindfulness-based joyful sleep or CBT-I for 2-hour sessions weekly for 8 weeks. The primary outcome is sleep quality assessed by the Pittsburgh Sleep Quality Index, severity of insomnia symptoms assessed by the Insomnia Severity Index and sleep parameters recorded using sleep diary and polysomnography. Secondary outcomes include perceived stress, anxiety and depression. The exploratory outcome is serum level of NF-κB. Outcomes will be evaluated at baseline, the end of the ntervention period and at a 3 month follow-up. Data will be analysed using general linear models, specifically analysis of covariance and analysis of variance will be used. ETHICS AND DISSEMINATION: Full ethical approval for this study has been obtained from the Ethics Committee of the Third Xiangya Hospital, Central South University, Changsha, China (2018-S236). If Mindfulness-Based Joyful Sleep is proven effective, its dissemination will help bridge the gap between the unmet need and the demand for insomnia interventions in China. TRIAL REGISTRATION NUMBER: NCT03268629; Pre-results.

Indexed as

AdolescentAdultChinaEmotionsFemaleFollow-Up StudiesHumansInflammationMaleMiddle AgedMindfulnessNF-kappa BPolysomnographyProspective StudiesRandomized Controlled Trials as TopicSingle-Blind MethodNF-kappa Binsomniamindfulnessmindfulness meditationNF-KBTai Chi

Identifiers

PMID31296508
PMCPMC6624060
OpenAlexW2960514164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.