Evidence map›Paper›PMID 31296496›Full record

ArticleBlood advances2019

In vivo dynamics of T cells and their interactions with dendritic cells in mouse cutaneous graft-versus-host disease.

Sarah Morin-Zorman, Christian Wysocki, Jieqing Zhu, Hongmei Li, Sylvain Zorman, Catherine Matte-Martone, Edwina Kisanga, Jennifer McNiff, Dhanpat Jain, David Gonzalez and 4 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Sarah Morin-ZormanDivision of Hematology, Department of Oncology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Christian WysockiDepartment of Medicine, University of Texas Southwestern, Dallas, TX.
Jieqing ZhuStarzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Hongmei LiBeth Israel Deaconess Medical Center, Boston, MA.
Sylvain ZormanRhizom, Saint-Genis-Pouilly, France.
Catherine Matte-MartoneYale University School of Medicine, New Haven, CT.
Edwina KisangaYale University School of Medicine, New Haven, CT.
Jennifer McNiffDepartment of Dermatology.
Dhanpat JainDepartment of Pathology, and.
David GonzalezDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT; and.
David M RothsteinStarzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Fadi G LakkisStarzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Ann HabermanDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT; and.ORCID 0000-0001-5168-8229
Warren D ShlomchikStarzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA.ORCID 0000-0002-0430-9078
University of Pittsburgh · USYale University · USBeth Israel Deaconess Medical Center · USHôpital Beau-Séjour · CHThe University of Texas Southwestern Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Role of Tissue Antigen Presenting Cells in GVHDR01HL083072 · NHLBI · YALE UNIVERSITY · PI SHLOMCHIK, WARREN D · 2006 to 2015
$2.9M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL083072
6 · The paper itself

Abstract

Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (alloSCT). By static microscopy, cutaneous GVHD lesions contain a mix of T cells and myeloid cells. We used 2-photon intravital microscopy to investigate the dynamics of CD4

Indexed as

AnimalsBiomarkersCD11c AntigenCell CommunicationDendritic CellsDisease Models, AnimalFluorescent Antibody TechniqueGene ExpressionGenes, ReporterGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHistocompatibility Antigens Class IImmunophenotypingLymphocyte DepletionMiceMice, TransgenicBiomarkersCD11c AntigenHistocompatibility Antigens Class IReceptors, Antigen, T-Cell

Identifiers

PMID31296496
PMCPMC6650737
OpenAlexW2957544363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.