ArticleRadiation oncology (London, England)2019
Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
- Helium pencil beam commissioning and beam modeling.Physics and imaging in radiation oncology · 2026Article
- LET measurements in proton and helium-ion beams of therapeutic energies using a silicon pixel detector towards a tool for quality assurance.Medical physics · 2025Article
- Evaluation of relative biological effectiveness ofEJNMMI physics · 2025Article
- Development and benchmarking of a dose rate engine for raster-scanned FLASH helium ions.Medical physics · 2024Article
- Intensity modulated proton therapy for early-stage glottic cancer: high-precision approach to laryngeal function preservation with exceptional treatment tolerability.Radiation oncology (London, England) · 2022Article
- Impact of DNA Repair Kinetics and Dose Rate on RBE Predictions in the UNIVERSE.International journal of molecular sciences · 2022Article
- How can we consider variable RBE and LETRadiation oncology (London, England) · 2022Article
- Dataset for predicting single-spot proton ranges in proton therapy of prostate cancer.Scientific data · 2021Article
- Towards real-time PGS range monitoring in proton therapy of prostate cancer.Scientific reports · 2021Article
- The Emerging Potential of Multi-Ion Radiotherapy.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHelium (
methodsCharacterization of biological effect for
resultsOur data indicate clinically relevant uncertainty of ±5-10% across different model simulations, highlighting their distinct biological and computational methodologies. The in vitro surrogate for highly radio-resistant tissues presented large RBE variability and uncertainty within the clinical dose range.
conclusionsExisting phenomenological and mechanistic/biophysical models were successfully integrated and validated in both Monte Carlo and GPU-accelerated analytical platforms against in vitro experiments, and tested using pristine peaks and clinical fields in highly radio-resistant tissues where models exhibit the greatest RBE uncertainty. Together, these efforts mark an important step towards clinical translation of raster-scanning
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.