SynthesisBMC pulmonary medicine2019
Effects of low-dose computed tomography on lung cancer screening: a systematic review, meta-analysis, and trial sequential analysis.
Synthesis in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 8 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- An umbrella review of systematic evidence on the Low Dose Computed Tomography (LDCT) for lung cancer screening.Future oncology (London, England) · 2025Pooled it
- Pooled it
- Ultrathin Bronchoscopy for the Diagnosis of Peripheral Pulmonary Lesions: A Meta-Analysis.Respiration; international review of thoracic diseases · 2023Pooled it
- Diagnostic significance of microRNAs in sepsis.PloS one · 2023Pooled it
- Cost-Effectiveness Analyses of Lung Cancer Screening Using Low-Dose Computed Tomography: A Systematic Review Assessing Strategy Comparison and Risk Stratification.PharmacoEconomics - open · 2022Pooled it
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis.Annals of family medicine · 2020Pooled it
- Lung Cancer Screening with Low-Dose CT: a Meta-Analysis.Journal of general internal medicine · 2020Pooled it
- Lung cancer screening primer: Key information for primary care providers.Canadian family physician Medecin de famille canadien · 2021Trial
- Earlier diagnosis of lung cancer in a randomised trial of an autoantibody blood test followed by imaging.The European respiratory journal · 2021Trial
- The early diagnostic value of lung cancer autoantibodies and tumor markers in lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Lung tumour secretome and extracellular vesicles: mechanisms, biomarkers, and therapeutic opportunities.Cancer metastasis reviews · 2026Review
- Lung Cancer Diagnosis Rates in Early Detection Programs in the Mississippi Delta.JAMA network open · 2026Article
- Māori perspectives on a potential low dose CT lung cancer screening programme in Aotearoa New Zealand: results of a mixed-method cross-sectional survey.BMC public health · 2026Article
- European Code Against Cancer, 5th edition - organised cancer screening programmes.Molecular oncology · 2026Review
- Observational Study on Actual Cancer Screening Participation and Outcomes Among Patients with Lung Cancer Based on Linkage of Cancer Registry and Kyoto City Integrated Database Data from 2014 to 2018.International journal of environmental research and public health · 2025Observational
- From Lab to Clinic: Artificial Intelligence with Spectroscopic Liquid Biopsies.Diagnostics (Basel, Switzerland) · 2025Review
- Multi-cancer early detection based on serum surface-enhanced Raman spectroscopy with deep learning: a large-scale case-control study.BMC medicine · 2025Article
- Te Oranga Pūkahukahu research programme: intentional steps towards a national equity-focused lung cancer screening programme in Aotearoa New Zealand.Journal of the Royal Society of New Zealand · 2025Article
- Systems mapping: a novel approach to national lung cancer screening implementation in Australia.Translational lung cancer research · 2024Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Nelson mortality results were presented in September 2018. Four other randomized control trials (RCTs) were also reported the latest mortality outcomes in 2018 and 2019. We therefore conducted a meta-analysis to update the evidence and investigate the benefits and harms of low-dose computed tomography (LDCT) in lung cancer screening.
methodsDetailed electronic database searches were performed to identify reports of RCTs that comparing LDCT to any other type of lung cancer screening. Pooled risk ratios (RRs) were calculated using random effects models.
resultsWe identified nine RCTs (n = 97,244 participants). In pooled analyses LDCT reduced lung cancer mortality (RR 0.83, 95% CI 0.76-0.90, I
conclusionsIn meta-analysis based on sufficient evidence demonstrated by TSA suggests that LDCT screening is superiority over usual care in lung cancer survival. The benefit of LDCT is expected to be heavily influenced by the risk of lung cancer in the different target group (smoking status, Asian) being screened.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.