Evidence map›Paper›PMID 31296139›Full record

ArticleLupus2019

Delayed lupus nephritis in the course of systemic lupus erythematosus is associated with a poorer treatment response: a multicentre, retrospective cohort study in Japan.

M Nakano, K Kubo, Y Shirota, Y Iwasaki, Y Takahashi, T Igari, Y Inaba, Y Takeshima, S Tateishi, H Yamashita and 8 more

Erratum issuedOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

M Nakano1 Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8558-5316
K Kubo2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Y Shirota3 Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Y Iwasaki2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5786-0760
Y Takahashi1 Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
T Igari4 Pathology Division of Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan.
Y Inaba5 Biostatistics Section, Department of Clinical Research and Informatics, Clinical Science Center, National Center for Global Health and Medicine, Tokyo, Japan.
Y Takeshima2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
S Tateishi2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
H Yamashita1 Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
M Miyazaki8 Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
H Sato9 Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
H Kanda2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
H Kaneko1 Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
T Ishii3 Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
K Fujio2 Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
N Tanaka5 Biostatistics Section, Department of Clinical Research and Informatics, Clinical Science Center, National Center for Global Health and Medicine, Tokyo, Japan.
A Mimori1 Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.
National Center for Global Health and Medicine · JPThe University of Tokyo · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to investigate possible differences in treatment responses between two categories for the onset of lupus nephritis.

methodsWe performed a multicentre, retrospective cohort study of class III-V lupus nephritis patients diagnosed between 1997 and 2014. The renal responses to initial induction therapy were compared between patients who developed lupus nephritis within one year from diagnosis of systemic lupus erythematosus (early (E-) LN) and the remainder (delayed (D-) LN) using the Kaplan-Meier method. We determined the predictors of renal response as well as renal flares and long-term renal outcomes using multivariate Cox regression analyses.

resultsA total of 107 E-LN and 70 D-LN patients were followed up for a median of 10.2 years. Log-rank tests showed a lower cumulative incidence of complete response in D-LN compared with E-LN patients. Multivariate analysis identified D-LN (hazard ratio (HR) 0.48, 95% confidence interval (CI) 0.33-0.70), nephrotic syndrome at baseline, and a chronicity index greater than 2 as negative predictors of complete response. D-LN patients were more likely to experience renal flares. D-LN (HR 2.54, 95% CI 1.10-5.83) and decreased renal function were significant predictors of chronic kidney disease at baseline.

conclusionD-LN was a predictor of poorer treatment outcomes, in addition to renal histology and severity of nephritis at lupus nephritis onset.

Indexed as

AdolescentAdultCohort StudiesFemaleHumansImmunosuppressive AgentsJapanLupus Erythematosus, SystemicLupus NephritisMaleMiddle AgedRetrospective StudiesTime FactorsTreatment OutcomeYoung AdultImmunosuppressive Agentsdelayed lupus nephritisLupus nephritissystemic lupus erythematosustreatment response

Identifiers

PMID31296139
PMCPMC6681441
OpenAlexW2957786831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.