Evidence map›Paper›PMID 31296047›Full record

ArticleCirculation. Cardiovascular imaging2019

Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9-Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography.

Nabil E Boutagy, Silvia Ravera, Xenophon Papademetris, John A Onofrey, Zhen W Zhuang, Jing Wu, Attila Feher, Mitchel R Stacy, Brent A French, Brian H Annex and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Nabil E BoutagyDepartment of Medicine, Section of Cardiovascular Medicine, Yale Translational Research Imaging Center (N.E.B., Z.W.Z., A.F., M.R.S., A.J.S.), Yale School of Medicine, New Haven, CT.
Silvia RaveraDepartment of Cellular and Molecular Physiology (S.R., N.C.), Yale School of Medicine, New Haven, CT.
Xenophon PapademetrisDepartment of Radiology and Biomedical Imaging (X.P., J.A.O., J.W., A.J.S.), Yale School of Medicine, New Haven, CT.
John A OnofreyDepartment of Radiology and Biomedical Imaging (X.P., J.A.O., J.W., A.J.S.), Yale School of Medicine, New Haven, CT.
Zhen W ZhuangDepartment of Medicine, Section of Cardiovascular Medicine, Yale Translational Research Imaging Center (N.E.B., Z.W.Z., A.F., M.R.S., A.J.S.), Yale School of Medicine, New Haven, CT.
Jing WuDepartment of Radiology and Biomedical Imaging (X.P., J.A.O., J.W., A.J.S.), Yale School of Medicine, New Haven, CT.
Attila FeherDepartment of Medicine, Section of Cardiovascular Medicine, Yale Translational Research Imaging Center (N.E.B., Z.W.Z., A.F., M.R.S., A.J.S.), Yale School of Medicine, New Haven, CT.
Mitchel R StacyDepartment of Medicine, Section of Cardiovascular Medicine, Yale Translational Research Imaging Center (N.E.B., Z.W.Z., A.F., M.R.S., A.J.S.), Yale School of Medicine, New Haven, CT.
Brent A FrenchDepartment of Biomedical Engineering (B.A.F., B.H.A.), University of Virginia, Charlottesville.
Brian H AnnexDepartment of Biomedical Engineering (B.A.F., B.H.A.), University of Virginia, Charlottesville.
Nancy CarrascoDepartment of Cellular and Molecular Physiology (S.R., N.C.), Yale School of Medicine, New Haven, CT.
Albert J SinusasDepartment of Medicine, Section of Cardiovascular Medicine, Yale Translational Research Imaging Center (N.E.B., Z.W.Z., A.F., M.R.S., A.J.S.), Yale School of Medicine, New Haven, CT.
Yale University · USUniversity of Virginia · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
THYROID SODIUM I/ SYMPORTERR01DK041544 · NIDDK · YESHIVA UNIVERSITY · PI ABBOTT, GEOFFREY W, CARRASCO, NANCY · 1989 to 2017
$5.6M
Training In Multi-modality Molecular & Translational Cardiovascular ImagingT32HL098069 · NHLBI · YALE UNIVERSITY · PI JAMES S DUNCAN, Georges El Fakhri · 2010 to 2026
$5.2M
A Bioengineering Approach to Gene Therapy for Peripheral Arterial DiseaseR01HL116455 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H, FRENCH, BRENT A · 2014 to 2017
$2.7M
The Anti-angiogenic VEGF165b and VEGFR1 Signaling in Peripheral Artery DiseaseR01HL141325 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H · 2019 to 2022
$2.7M
Multi-context software for robust and reproducible neuroscience image analysisR24MH114805 · NIMH · YALE UNIVERSITY · PI PAPADEMETRIS, XENOPHON, SCHEINOST, DUSTIN · 2017 to 2019
$1.2M
Ultra-high Performance MicroSPECT/CT systemS10OD021845 · OD · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2016 to 2016
$600k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL116455NHLBI NIH HHS R01 HL141325NHLBI NIH HHS T32 HL098069NIDDK NIH HHS R01 DK041544NIH HHS S10 OD021845NIMH NIH HHS R24 MH114805
6 · The paper itself

Abstract

backgroundWe propose micro single-photon emission computed tomography/computed tomography imaging of the hNIS (human sodium/iodide symporter) to noninvasively quantify adeno-associated virus 9 (AAV9)-mediated gene expression in a murine model of peripheral artery disease.

methodsAAV9-hNIS (2×10

resultsAs quantitated by standardized uptake value, there was a gradual temporal increase in

conclusionsMicro single-photon emission computed tomography/computed tomography imaging of hNIS-mediated

Indexed as

AnimalsDependovirusDisease Models, AnimalGene Expression RegulationHindlimbIschemiaMiceMice, Inbred C57BLMuscle, SkeletalNeuraminidasePeripheral Arterial DiseaseSaline SolutionSingle Photon Emission Computed Tomography Computed TomographySodium-Iodide SymportersSymportersNeuraminidaseSaline SolutionSodium-Iodide SymportersSymportersanimalsgenetic therapyneuraminidaseperipheral artery diseasetomography, emission computed, single-photon

Identifiers

PMID31296047
PMCPMC6629470
OpenAlexW2958421341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.