ArticleJournal of clinical medicine2019
Independent Association of Physical Activity with Nonalcoholic Fatty Liver Disease and Alanine Aminotransferase Levels.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Risk Factors and Prediction Models for Nonalcoholic Fatty Liver Disease Based on Random Forest.Computational and mathematical methods in medicine · 2022Trial
- Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis.Preventive medicine reports · 2025Review
- Metformin: Beyond Type 2 Diabetes Mellitus.Cureus · 2024Review
- Voluntary physical activity in early life attenuates markers of fatty liver disease in adult male rats fed a high-fat diet.The British journal of nutrition · 2023Article
- Higher mortality among lean patients with non-alcoholic fatty liver disease despite fewer metabolic comorbidities.Alimentary pharmacology & therapeutics · 2023Article
- Association between physical activity and serum liver aminotransferases in Southwestern Iran: A Cross-sectional study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Joint Effect of Hepatic Steatosis and Alanine Aminotransferase Within the Normal Range on Incident Ischemic Heart Disease: A Prospective Study in Koreans.Clinical interventions in aging · 2021Article
- NAFLD and Physical Exercise: Ready, Steady, Go!Frontiers in nutrition · 2021Review
- Aerobic Exercise in the Management of Metabolic Dysfunction Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- Trends in the Prevalence of Non-Alcoholic Fatty Liver Disease and Its Future Predictions in Korean Men, 1998-2035.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to examine the independent association of physical activity with nonalcoholic fatty liver disease (NAFLD) and aminotransferases while adjusting for obesity and diet. Cross-sectional data from 32,391 participants aged ≥ 20 years in the Korea National Health and Nutrition Examination Surveys (KNHANES) was analyzed by logistic regression models and general linear models. Physical activity was assessed from the questionnaire by health-enhancing physical activity (HEPA). The physical activity was negatively associated with NAFLD and lean NAFLD after adjustment for multiple factors with an odds ratio of 0.7 (95% CI, 0.6-0.8) and 0.5 (95% CI, 0.4-0.7) comparing the most active (HEPA active) and the least active (inactive) participants. Among the participants with NAFLD, physical activity also showed an independent negative association with alanine aminotransferase (ALT) levels but not with aspartate aminotransferase levels. These independent associations were not observed when comparing the minimally active and inactive participants except for the risk of lean NAFLD. Physical activity is independently associated with the degree of hepatocellular injury in patients with NAFLD as well as the risk of NAFLD and lean NAFLD in the general population. Sufficiently active physical activity greater than a minimally active level may be needed to lower the risk of NAFLD and ALT levels.
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Registered trials
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