Evidence map›Paper›PMID 31295961›Full record

ArticleJournal of clinical medicine2019

Regulation of Th17 Cytokine-Induced Osteoclastogenesis via SKI306X in Rheumatoid Arthritis.

Hae-Rim Kim, Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong-Ki Min, Kyung-Ann Lee, Tae-Young Kim, Sang-Heon Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hae-Rim KimDivision of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, School of Medicine, Konkuk University, Seoul 05030, Korea.
Kyoung-Woon KimConversant Research Consortium in Immunologic Disease, Seoul St. Mary's Hospital, The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 06591, Korea.
Bo-Mi KimConversant Research Consortium in Immunologic Disease, Seoul St. Mary's Hospital, The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 06591, Korea.
Ji-Yeon WonConversant Research Consortium in Immunologic Disease, Seoul St. Mary's Hospital, The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 06591, Korea.
Hong-Ki MinDivision of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, School of Medicine, Konkuk University, Seoul 05030, Korea.
Kyung-Ann LeeDivision of Rheumatology, Department of Internal medicine, Soonchunhyang University Hospital, Seoul 04401, Korea.
Tae-Young KimDepartment of Orthopedic Surgery, School of Medicine, Konkuk University, Seoul 05030, Korea.
Sang-Heon LeeDivision of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, School of Medicine, Konkuk University, Seoul 05030, Korea. shlee@kuh.ac.kr.
Konkuk University · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the regulatory effect of SKI305X, a mixed extract of three herbs, in T helper (Th)17 cytokine-induced inflammation and joint destruction in rheumatoid arthritis (RA). Synovial fibroblasts were isolated from RA patients and cultured with Th17 cytokines including interleukin (IL)-17, IL-21, and IL-22 and SKI306X, and tumor necrosis factor (TNF)-, IL-1, and receptor activator of nuclear factor kappa-Β ligand (RANKL) expression and production were investigated using real-time PCR and ELISA of culture media. After peripheral blood (PB) cluster of differentiation (CD)14

Indexed as

cytokineherbal medicineosteoclastrheumatoid arthritissynovial fibroblasts

Identifiers

PMID31295961
PMCPMC6678573
OpenAlexW2957354470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.