Evidence map›Paper›PMID 31295945›Full record

ArticleCells2019

Physicochemical Properties of Nucleoli in Live Cells Analyzed by Label-Free Optical Diffraction Tomography.

Tae-Keun Kim, Byong-Wook Lee, Fumihiko Fujii, Jun Ki Kim, Chan-Gi Pack

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. The Enhancement of Antimicrobial Photodynamic Therapy ofInternational journal of molecular sciences · 2022
    Article
  7. Review
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  9. Article
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  11. Article
  12. Refractive Index Changes of Cells and Cellular Compartments Upon Paraformaldehyde Fixation Acquired by Tomographic Phase Microscopy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021
    Article
  13. Label-Free Multiphoton Microscopy: Much More Than Fancy Images.International journal of molecular sciences · 2021
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Tae-Keun KimAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Byong-Wook LeeAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.
Fumihiko FujiiDivision of Physical Pharmacy, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
Jun Ki KimAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea. kim@amc.seoul.kr.ORCID 0000-0002-0099-9681
Chan-Gi PackAsan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea. changipack@amc.seoul.kr.ORCID 0000-0002-6578-3099
Asan Medical Center · KRUlsan College · KRKobe Gakuin University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cell nucleus is three-dimensionally and dynamically organized by nuclear components with high molecular density, such as chromatin and nuclear bodies. The structure and functions of these components are represented by the diffusion and interaction of related factors. Recent studies suggest that the nucleolus can be assessed using various protein probes, as the probes are highly mobile in this organelle, although it is known that they have a densely packed structure. However, physicochemical properties of the nucleolus itself, such as molecular density and volume when cellular conditions are changed, are not yet fully understood. In this study, physical parameters such as the refractive index (RI) and volume of the nucleoli in addition to the diffusion coefficient (

Indexed as

Cell NucleolusCell NucleusCytoplasmHeLa CellsHumansImaging, Three-DimensionalIntranuclear Inclusion BodiesMicroscopy, ConfocalRefractometrySpectrometry, FluorescenceTomography, Opticaldiffusion coefficientfluorescence correlation spectroscopyliquid-liquid phase separationnucleolusoptical diffraction tomographyrefractive indexvolume

Identifiers

PMID31295945
PMCPMC6679011
OpenAlexW2956474901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.