Evidence map›Paper›PMID 31295913›Full record

ReviewInternational journal of molecular sciences2019

Platinum Salts in Patients with Breast Cancer: A Focus on Predictive Factors.

Mattia Garutti, Giacomo Pelizzari, Michele Bartoletti, Matilde Clarissa Malfatti, Lorenzo Gerratana, Gianluca Tell, Fabio Puglisi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mattia GaruttiU.O.C Oncologia Medica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy.
Giacomo PelizzariDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy.
Michele BartolettiDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy.
Matilde Clarissa MalfattiDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy.
Lorenzo GerratanaDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy.ORCID 0000-0002-8313-4834
Gianluca TellDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy.ORCID 0000-0001-8845-6448
Fabio PuglisiDepartment of Medicine (DAME), University of Udine, 33100 Udine, Italy. fabio.puglisi@cro.it.ORCID 0000-0003-0573-4938
University of Udine · ITAgostino Gemelli University Polyclinic · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG19862
6 · The paper itself

Abstract

Breast cancer (BC) is the most frequent oncologic cause of death among women and the improvement of its treatments is compelling. Platinum salts (e.g., carboplatin, cisplatin, and oxaliplatin) are old drugs still used to treat BC, especially the triple-negative subgroup. However, only a subset of patients see a concrete benefit from these drugs, raising the question of how to select them properly. Therefore, predictive biomarkers for platinum salts in BC still represent an unmet clinical need. Here, we review clinical and preclinical works in order to summarize the current evidence about predictive or putative platinum salt biomarkers in BC. The association between

Indexed as

AnimalsAntineoplastic AgentsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsClinical Trials as TopicDNA RepairDrug Resistance, NeoplasmFemaleHomologous RecombinationHumansMutationOrganoplatinum CompoundsPharmacogeneticsAntineoplastic AgentsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinOrganoplatinum Compoundsbase excision repairBRCABRCAnessbreast cancerhomologous recombination repairplatinum

Identifiers

PMID31295913
PMCPMC6678596
OpenAlexW2958370806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.