Evidence map›Paper›PMID 31295870›Full record

ArticleBiomolecules2019

Analysis and Identification of Active Compounds from Gami-Soyosan Toxic to MCF-7 Human Breast Adenocarcinoma Cells.

Mi-Yeon Jung, Chang-Seob Seo, Seon-Eun Baek, Jaemin Lee, Myoung-Sook Shin, Ki Sung Kang, Sullim Lee, Jeong-Eun Yoo

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mi-Yeon JungDepartment of Obstetrics and Gynecology, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea.
Chang-Seob SeoHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.ORCID 0000-0002-8156-446X
Seon-Eun BaekDepartment of Obstetrics and Gynecology, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea.
Jaemin LeeCollege of Korean Medicine, Gachon University, Seongnam 13120, Korea.
Myoung-Sook ShinCollege of Korean Medicine, Gachon University, Seongnam 13120, Korea.ORCID 0000-0002-5103-437X
Ki Sung KangCollege of Korean Medicine, Gachon University, Seongnam 13120, Korea.
Sullim LeeDepartment of Life Science, College of Bio-Nano Technology, Gachon University, Seongnam 13120, Korea. sullimlee@gachon.ac.kr.ORCID 0000-0002-4187-2177
Jeong-Eun YooDepartment of Obstetrics and Gynecology, College of Korean Medicine, Daejeon University, Daejeon 35235, Korea. jeyoo@dju.ac.kr.
Gachon University · KRDaejeon University · KRKorea Institute of Oriental Medicine · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gami-soyosan is a medicinal herbal formulation prescribed for the treatment of menopausal symptoms, including hot flashes and osteoporosis. Gami-soyosan is also used to treat similar symptoms experienced by patients with breast cancer. The incidence of breast cancer in women receiving hormone replacement therapy is a big burden. However, little is known about the components and their mechanism of action that exhibit these beneficial effects of Gami-soyosan. The aim of this study was to simultaneously analyze compounds of Gami-soyosan, and determine their cytotoxic effects on estrogen receptor (ER)-positive MCF-7 human breast adenocarcinoma cells. We established a simultaneous analysis method of 18 compounds contained in Gami-soyosan and found that, among the various compounds in Gami-soyosan, gallic acid (

Indexed as

AdenocarcinomaAntineoplastic AgentsApoptosisBenzopyransBlotting, WesternBreast NeoplasmsButyratesCell ProliferationChromatography, High Pressure LiquidHumansMCF-7 CellsPlant ExtractsAntineoplastic AgentsBenzopyransButyratesdecursinPlant Extractsapoptosisbreast cancerdecursindecursinol angelategallic acidGami-soyosanMCF-7

Identifiers

PMID31295870
PMCPMC6681368
OpenAlexW2957655679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.