ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2019
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Understanding intracortical excitability in phantom limb pain: A multivariate analysis from a multicenter randomized clinical trial.Neurophysiologie clinique = Clinical neurophysiology · 2021Trial
- Increased Expression of Synaptic Vesicle Glycoprotein 2A (SV2A) in the Brain of Chronic Diabetic Rats.Synapse (New York, N.Y.) · 2025Article
- Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy.Frontiers in human neuroscience · 2025Article
- Alterations of the glutamatergic system in diabetes mellitus.Metabolic brain disease · 2024Review
- Adaptive Autonomic and Neuroplastic Control in Diabetic Neuropathy: A Narrative Review.Current diabetes reviews · 2024Review
- Altered Functional Connectivity Density in Type 2 Diabetes Mellitus with and without Mild Cognitive Impairment.Brain sciences · 2023Article
- Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting.International journal of obesity (2005) · 2022Review
- A comprehensive review of transcranial magnetic stimulation in secondary dementia.Frontiers in aging neuroscience · 2022Review
- Prospects for the application of transcranial magnetic stimulation in diabetic neuropathy.Neural regeneration research · 2021Review
- Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes.International journal of molecular sciences · 2020Article
- The neurometabolic profiles of GABA and Glutamate as revealed by proton magnetic resonance spectroscopy in type 1 and type 2 diabetes.PloS one · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesIn older adults, type-2 diabetes mellitus (T2DM) impacts cognition and increases dementia risk. Prior studies suggest that impaired neuroplasticity may contribute to the cognitive decline in T2DM, but the underlying mechanisms of altered neuroplasticity are unclear. We investigated the relationship of the concentration of glutamatergic metabolites with measures of cortical plasticity in older adults across the spectrum of glucose intolerance/insulin resistance.
methodsForty adults (50-87 years: 17-T2DM, 14-pre-diabetes, 9-controls) underwent magnetic resonance spectroscopy to quantify glutamate and other key metabolites within a 2 cm
resultsGroup differences were observed in relative concentrations of glutamine (p = .028), glucose (p = .008), total cholines (p = .048), and the glutamine/glutamate ratio (p = .024). Cortical plasticity was reduced in both T2DM and pre-diabetes groups relative to controls (p-values < .05). Only the T2DM group showed a significant positive association between glutamate concentration and plasticity (r = .56, p = .030).
conclusionsNeuroplastic mechanisms are already impaired in pre-diabetes. In T2DM, reduced cortico-motor plasticity is associated with lower cortical glutamate concentration. SIGNIFICANCE: Impaired plasticity in T2DM is associated with low glutamatergic metabolite levels. The glutamatergic neurotransmission system constitutes a potential therapeutic target for cognitive problems linked to plasticity-related deficiencies in T2DM.
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