ArticleNeuroImage2019
Using machine learning-based lesion behavior mapping to identify anatomical networks of cognitive dysfunction: Spatial neglect and attention.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Brain Network Connectivity During Resting-State and a Visuospatial Task as a Biomarker for Spatial Neglect in Stroke Patients.Neurorehabilitation and neural repair · 2026Trial
- A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.NPJ digital medicine · 2026Article
- Convergent causal mapping unravels distinct frontal networks for visuospatial selective attention.Nature communications · 2025Article
- Spatial neglect after subcortical stroke may reflect cortico-cortical disconnection.Scientific reports · 2025Article
- Susceptibility to multitasking in stroke is associated to multiple-demand system damage and leads to lateralized visuospatial deficits.Communications biology · 2025Article
- Right hemisphere stroke is linked to reduced social connectedness in the UK Biobank cohort.Scientific reports · 2024Article
- Review
- The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke.Human brain mapping · 2024Article
- The parietal architecture binding cognition to sensorimotor integration: a multimodal causal study.Brain : a journal of neurology · 2024Article
- Virtual reality gameplay classification illustrates the multidimensionality of visuospatial neglect.Brain communications · 2024Article
- Stable multivariate lesion symptom mapping.Aperture neuro · 2024Article
- Data-driven biomarkers better associate with stroke motor outcomes than theory-based biomarkers.Brain communications · 2024Article
- Using predictive validity to compare associations between brain damage and behavior.Human brain mapping · 2023Article
- Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes.bioRxiv : the preprint server for biology · 2023Article
- Location-weighted versus Volume-weighted Mismatch at MRI for Response to Mechanical Thrombectomy in Acute Stroke.Radiology · 2023Observational
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- Disconnectomics to unravel the network underlying deficits of spatial exploration and attention.Scientific reports · 2022Article
- Indirect structural disconnection-symptom mapping.Brain structure & function · 2022Review
- The Role of Extra-Operative Cortical Stimulation and Mapping in the Surgical Management of Intracranial Gliomas.Brain sciences · 2022Article
- Distinct roles of right temporoparietal cortex in pentagon copying test.Brain imaging and behavior · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Previous lesion behavior studies primarily used univariate lesion behavior mapping techniques to map the anatomical basis of spatial neglect after right brain damage. These studies led to inconsistent results and lively controversies. Given these inconsistencies, the idea of a wide-spread network that might underlie spatial orientation and neglect has been pushed forward. In such case, univariate lesion behavior mapping methods might have been inherently limited in detecting the presumed network due to limited statistical power. By comparing various univariate analyses with multivariate lesion-mapping based on support vector regression, we aimed to validate the network hypothesis directly in a large sample of 203 newly recruited right brain damaged patients. If the exact same correction factors and parameter combinations (FDR correction and dTLVC for lesion size control) were used, both univariate as well as multivariate approaches uncovered the same complex network pattern underlying spatial neglect. At the cortical level, lesion location dominantly affected the temporal cortex and its borders into inferior parietal and occipital cortices. Beyond, frontal and subcortical gray matter regions as well as white matter tracts connecting these regions were affected. Our findings underline the importance of a right network in spatial exploration and attention and specifically in the emergence of the core symptoms of spatial neglect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.