Evidence map›Paper›PMID 31295316›Full record

SynthesisPloS one2019

Prevalence of permanent childhood hearing loss detected at the universal newborn hearing screen: Systematic review and meta-analysis.

Emma Butcher, Carol Dezateux, Mario Cortina-Borja, Rachel L Knowles

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Optimal Timing for Neonatal Hearing Screening in Well-Babies.International journal of neonatal screening · 2026
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  9. Review
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  12. Characteristics of Hearing Aid Use in Adolescents Who Are Deaf and Hard of Hearing.Language, speech, and hearing services in schools · 2025
    Article
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  14. Newborn screening for hearing and sight, Cameroon.Bulletin of the World Health Organization · 2025
    Article
  15. Article
  16. Polygenic Risk Scores and Hearing Loss Phenotypes in Children.JAMA otolaryngology-- head & neck surgery · 2024
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emma ButcherLife Course Epidemiology and Biostatistics, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID 0000-0002-0622-3198
Carol DezateuxLife Course Epidemiology and Biostatistics, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Mario Cortina-BorjaClinical Epidemiology, Nutrition and Biostatistics, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Rachel L KnowlesLife Course Epidemiology and Biostatistics, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.ORCID 0000-0002-5490-7682
Great Ormond Street Hospital · GBQueen Mary University of London · GB

Funding

Department of Health
6 · The paper itself

Abstract

contextPermanent childhood hearing loss (PCHL) can affect speech, language, and wider outcomes. Adverse effects are mitigated through universal newborn hearing screening (UNHS) and early intervention.

objectiveWe undertook a systematic review and meta-analysis to estimate prevalence of UNHS-detected PCHL (bilateral loss ≥26 dB HL) and its variation by admission to neonatal intensive care unit (NICU). A secondary objective was to report UNHS programme performance (PROSPERO: CRD42016051267). DATA SOURCES: Multiple electronic databases were interrogated in January 2017, with further reports identified from article citations and unpublished literature (November 2017). STUDY SELECTION: UNHS reports from very highly-developed (VHD) countries with relevant prevalence and performance data; no language or date restrictions. DATA EXTRACTION: Three reviewers independently extracted data and assessed quality.

resultsWe identified 41 eligible reports from 32 study populations (1799863 screened infants) in 6195 non-duplicate references. Pooled UNHS-detected PCHL prevalence was 1.1 per 1000 screened children (95% confidence interval [CI]: 0.9, 1.3; I2 = 89.2%). This was 6.9 times (95% CI: 3.8, 12.5) higher among those admitted to NICU. Smaller studies were significantly associated with higher prevalences (Egger's test: p = 0.02). Sensitivity and specificity ranged from 89-100% and 92-100% respectively, positive predictive values from 2-84%, with all negative predictive values 100%. LIMITATIONS: Results are generalisable to VHD countries only. Estimates and inferences were limited by available data.

conclusionsIn VHD countries, 1 per 1000 screened newborns require referral to clinical services for PCHL. Prevalence is higher in those admitted to NICU. Improved reporting would support further examination of screen performance and child demographics.

Indexed as

Cost-Benefit AnalysisChildChild, PreschoolFemaleHearing DisordersHearing LossHearing TestsHumansInfantInfant, NewbornMaleNeonatal Screening

Identifiers

PMID31295316
PMCPMC6622528
OpenAlexW2958938850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.