ArticlePloS one2019
Phytochemical profiling and seasonal variation of essential oils of three Callistemon species cultivated in Egypt.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 43 citations in OpenAlex.
- Chemical composition ofFrontiers in pharmacology · 2026Article
- Biological Activities of Callistemon citrinus and Callistemon viminalis Essential Oils: EMT-Linked Antitumor, Antioxidant, and Antibacterial Effects.Chemistry & biodiversity · 2026Article
- Comparative chemical and antimicrobial evaluation of the essential oils from Callistemon and podocarpus species supported by in-silico molecular simulations against bacterial LacY protease.BMC complementary medicine and therapies · 2025Article
- Volatiles extracted from Melaleuca Rugulosa (Link) Craven leaves: comparative profiling, bioactivity screening, and metabolomic analysis.BMC complementary medicine and therapies · 2024Article
- The impact of seasonal variation on the composition of the volatile oil of Polyalthia suberosa (Roxb.) Thwaites leaves and evaluation of its acetylcholinesterase inhibitory activity.BMC complementary medicine and therapies · 2024Article
- Chemical and biological characterization of Melaleuca subulata (Cheel) Craven leaves' volatile constituents supported by chemometric analysis and molecular docking.BMC complementary medicine and therapies · 2024Article
- Comparative Study of Essential Oils from Different Organs ofMolecules (Basel, Switzerland) · 2023Article
- Comparative Metabolic Study ofPlants (Basel, Switzerland) · 2022Article
- Chemical Constituents ofPlants (Basel, Switzerland) · 2022Article
- GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of aPlants (Basel, Switzerland) · 2022Article
- Susceptibility of Fluconazole-ResistantMicroorganisms · 2021Article
- Anti-Allergic, Anti-Inflammatory and Anti-Hyperglycemic Activity ofPlants (Basel, Switzerland) · 2021Article
- GC/MS Profiling andEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Deep learning model for classification and bioactivity prediction of essential oil-producing plants from Egypt.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genus Callistemon comprises evergreen shrubs or small trees, widely cultivated as ornamentals and for essential oil production. Callistemon is well-recognized in folk medicine for its anti-cough, anti-bronchitis, and insecticidal activities. In the current study, we profiled the essential oil composition of the leaves of C. citrinus, C. rigidus and C. viminalis (Myrtaceae) collected during different seasons by GLC-MS coupled to multivariate data analysis. Antioxidant, anti-inflammatory and anti-proliferative activities of Callistemon essential oils were evaluated. A total of 29 compounds were tentatively identified. Oxygenated monoterpenes dominated in essential oils, where eucalyptol represented the major constituent in the three Callistemon species in all seasons. Multivariate data analysis including Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) were applied to discriminate between different Callistemon species in each season and to investigate any correlation between the metabolic profile of each species within different seasons. As expected, PCA plot could discriminate the three Callistemon species in the four seasons. The dendrogram from HCA confirmed the results of PCA as it showed the same segregation pattern regarding the discrimination of different Callistemon species. C. viminalis showed more pronounced antioxidant activity than C. citrinus, exhibiting IC50 values of 1.40 mg/mL and 1.77 mg/mL, respectively. Meanwhile, C. rigidus showed very weak antioxidant activity. All oils showed membrane stabilization activity in hypotonic solution induced haemolysis assay, where C. viminalis showed potent membrane stabilizing activity exhibiting IC50 value of 25.6 μg/mL comparable to that of the standard drug, indomethacin (17.02 μg/mL). Nevertheless, Callistemon essential oils were not cytotoxic in HCT-116 and Hela human cancer cell lines.
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