ArticlePLoS biology2019
A novel Ca2+-binding protein that can rapidly transduce auxin responses during root growth.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Article
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- Identification of quantitative trait loci qPL6 for petiole length in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Duckweed genomes and epigenomes underlie triploid hybridization and clonal reproduction.Current biology : CB · 2025Article
- Genome-wide identification of SlIQMs and the regulatory effect of calcium on tomato seedlings under drought stress and phytohormone treatment.Plant cell reports · 2025Article
- Transcriptome analyses for revealing leaf abscission of Cyclocarya paliurus stem segments in vitro.BMC genomics · 2025Article
- Genetic dissection of domestication traits in interspecific chickpea populations.The plant genome · 2024Article
- Changes in cell wall composition due to a pectin biosynthesis enzyme GAUT10 impact root growth.Plant physiology · 2023Article
- Metabolic and Molecular Rearrangements of Sauvignon Blanc (Plants (Basel, Switzerland) · 2023Article
- Microtubule-associated ROP interactors affect microtubule dynamics and modulate cell wall patterning and root hair growth.Development (Cambridge, England) · 2022Article
- Investigating Grapevine Red Blotch Virus Infection inInternational journal of molecular sciences · 2022Article
- Cross-species transcriptomic analyses reveals common and opposite responses in Arabidopsis, rice and barley following oxidative stress and hormone treatment.BMC plant biology · 2022Article
- Planthopper-Secreted Salivary Calmodulin Acts as an Effector for Defense Responses in Rice.Frontiers in plant science · 2022Article
- The Story of Auxin-Binding Protein 1 (ABP1).Cold Spring Harbor perspectives in biology · 2021Review
- Molecular Evolution of Calcium Signaling and Transport in Plant Adaptation to Abiotic Stress.International journal of molecular sciences · 2021Review
- Illuminating the hidden world of calcium ions in plants with a universe of indicators.Plant physiology · 2021Review
- ROP INTERACTIVE PARTNER b Interacts with RACB and Supports Fungal Penetration into Barley Epidermal Cells.Plant physiology · 2020Article
- Roles and mechanisms of CaPlant signaling & behavior · 2020Article
- CaFrontiers in plant science · 2020Review
- Cortical Microtubule Organization during Petal Morphogenesis inInternational journal of molecular sciences · 2019Review
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
Signaling cross talks between auxin, a regulator of plant development, and Ca2+, a universal second messenger, have been proposed to modulate developmental plasticity in plants. However, the underlying molecular mechanisms are largely unknown. Here, we report that in Arabidopsis roots, auxin elicits specific Ca2+ signaling patterns that spatially coincide with the expression pattern of auxin-regulated genes. We have identified the single EF-hand Ca2+-binding protein Ca2+-dependent modulator of ICR1 (CMI1) as an interactor of the Rho of plants (ROP) effector interactor of constitutively active ROP (ICR1). CMI1 expression is directly up-regulated by auxin, whereas the loss of function of CMI1 associates with the repression of auxin-induced Ca2+ increases in the lateral root cap and vasculature, indicating that CMI1 represses early auxin responses. In agreement, cmi1 mutants display an increased auxin response including shorter primary roots, longer root hairs, longer hypocotyls, and altered lateral root formation. Binding to ICR1 affects subcellular localization of CMI1 and its function. The interaction between CMI1 and ICR1 is Ca2+-dependent and involves a conserved hydrophobic pocket in CMI1 and calmodulin binding-like domain in ICR1. Remarkably, CMI1 is monomeric in solution and in vitro changes its secondary structure at cellular resting Ca2+ concentrations ranging between 10-9 and 10-8 M. Hence, CMI1 is a Ca2+-dependent transducer of auxin-regulated gene expression, which can function in a cell-specific fashion at steady-state as well as at elevated cellular Ca2+ levels to regulate auxin responses.
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