ArticlePLoS biology2019
Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- General mechanisms of task engagement in the primate frontal cortex.Nature communications · 2024Article
- Anterior cingulate cortex causally supports flexible learning under motivationally challenging and cognitively demanding conditions.PLoS biology · 2022Article
- Functional characterization of the fronto-parietal reaching and grasping network: reversible deactivation of M1 and areas 2, 5, and 7b in awake behaving monkeys.Journal of neurophysiology · 2022Article
- Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.Science advances · 2021Article
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Authors and funding
5 authors.
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Abstract
In primates, both the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (dlPFC) are key regions of the frontoparietal cognitive control network. To study the role of the dACC and its communication with the dlPFC in cognitive control, we recorded local field potentials (LFPs) from the dlPFC before and during the reversible deactivation of the dACC, in macaque monkeys engaging in uncued switches between 2 stimulus-response rules, namely prosaccade and antisaccade. Cryogenic dACC deactivation impaired response accuracy during maintenance of-but not the initial switching to-the cognitively demanding antisaccade rule, which coincided with a reduction in task-related theta activity and the correct-error (C-E) difference in dlPFC beta-band power. During both rule switching and maintenance, dACC deactivation prolonged the animals' reaction time and reduced task-related alpha power in the dlPFC. Our findings support a role of the dACC in prefrontal oscillatory activities that are involved the maintenance of a new, challenging task rule.
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