ArticlePLoS neglected tropical diseases2019
The introduction of new hosts with human trade shapes the extant distribution of Toxoplasma gondii lineages.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An African perspective on the genetic diversity ofParasitology · 2023Pooled it
- Molecular epidemiology of Toxoplasma gondii in impala (Aepyceros melampus) from the Greater Kruger in South Africa: Detection of the Africa 4 lineage.PLoS neglected tropical diseases · 2026Article
- Migratory and opportunistic wild and domestic birds, asParasite epidemiology and control · 2026Article
- Population genetic structure of zoonoticScience in One Health · 2026Article
- Toxoplasma gondii from Gabonese forest, Central Africa: First report of an African wild strain.PLoS neglected tropical diseases · 2025Article
- Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.Nature communications · 2024Article
- First detection ofFrontiers in cellular and infection microbiology · 2024Article
- A ring trial to harmonize Toxoplasma gondii microsatellite typing: comparative analysis of results and recommendations for optimization.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Virulence evolution ofEvolutionary applications · 2023Article
- A unique Toxoplasma gondii haplotype accompanied the global expansion of cats.Nature communications · 2022Article
- Molecular prevalence, genetic characterization and patterns of Toxoplasma gondii infection in domestic small mammals from Cotonou, Benin.Parasite (Paris, France) · 2022Article
- Toxoplasma gondii in the faeces of wild felids from the Atlantic Forest, Brazil.Memorias do Instituto Oswaldo Cruz · 2022Article
- Toxoplasmosis: Current and Emerging Parasite Druggable Targets.Microorganisms · 2021Review
- Comprehensive Overview ofPathogens (Basel, Switzerland) · 2021Review
- First isolation and genotyping of Toxoplasma gondii strains from domestic animals in Tunisia.Scientific reports · 2021Article
- A hotspot of Toxoplasma gondii Africa 1 lineage in Benin: How new genotypes from West Africa contribute to understand the parasite genetic diversity worldwide.PLoS neglected tropical diseases · 2021Article
- Epidemiologic significance ofParasitology · 2021Review
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14 authors.
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Abstract
Toxoplasma gondii is a zoonotic protozoan with a worldwide occurrence, but the determinants of the current pattern in the geographical distribution of T. gondii lineages and strains remain poorly understood. To test the influence of human trade on T. gondii populations, we conducted a population genetic study of 72 T. gondii animal isolates from Senegal, a West African country in which the ongoing inland progress of invasive murine hosts (introduced in port cities of Senegal since the 16th century by European sailors) is well described. Isolates were mainly collected on free-range poultry, which are considered as relevant bioindicators of T. gondii strain diversity in the domestic environment. Sampling was conducted in two port cities of Senegal (Dakar and Saint-Louis) and in one inland region (Kedougou). Population genetic analyses using 15 microsatellite markers revealed different patterns between port cities where lineages non-virulent for mice (type II, type III, and Africa 4) were predominant, and Kedougou where the mouse-virulent Africa 1 lineage was the most common. By considering the current spatial pattern in the inland progress of invasive rodents in Senegal, our results suggest that the invasive house mouse Mus musculus domesticus counter-selects the Africa 1 lineage in the invaded areas. The comparison of the microsatellite alleles of type II strains from Senegal to type II strains from other areas in Africa and Western Europe, using discriminant analysis of principal components and Network analysis, point to a mainly Western European origin of the type II lineage in Senegal. Collectively, these findings suggest that human-mediated intercontinental migrations of murine hosts are important vectors of T. gondii strains. Differential susceptibility of endemic and introduced murine hosts to various T. gondii strains probably determines the persistence of these strains in the environment, and therefore their availability for human and animal infection.
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