Evidence map›Paper›PMID 31295221›Full record

ArticleSexually transmitted diseases2019

Excess Cancer Cases and Medical Costs Due to Suboptimal Human Papillomavirus Vaccination Coverage in California.

Eleonore B Baughan, Erin M Keizur, Christopher A Damico, Elizabeth Mayfield Arnold, Jamie S Ko, Jeffrey D Klausner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Eleonore B Baughan
Erin M KeizurUniversity of California, Division of Infectious Diseases, Los Angeles, CA.
Christopher A Damico
Elizabeth Mayfield ArnoldUT Southwestern Medical Center, Department of Family and Community Medicine, Dallas, TX.
Jamie S KoUniversity of California, Division of Infectious Diseases, Los Angeles, CA.
Jeffrey D KlausnerUniversity of California, Division of Infectious Diseases, Los Angeles, CA.
University of California, Los Angeles · USCornell University · USSouthwestern Medical Center · US

Funding

Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANTON, PETER A · 1991 to 2018
$39.9M
Pilot Study of STI Screening and Treatment for PMTCTR21HD084274 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KLAUSNER, JEFFREY DAVID, MEDINA-MARINO, ANDREW · 2015 to 2016
$352k
NIAID NIH HHS HHSN272201300014INIAID NIH HHS P30 AI028697NICHD NIH HHS R21 HD084274
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) vaccination coverage continues to be at low to moderate levels throughout the United States. HPV infection is linked to multiple types of cancers resulting in high economic and health burden. We aimed to estimate the excess number of cancer cases and associated medical costs due to current HPV vaccination coverage for a 20-year-old birth cohort in California.

methodsWe estimated the lifetime number of cancer cases caused by vaccine-preventable strains of HPV for a cohort of 20 year-olds in California. We then estimated the excess number of cancer cases in that cohort which would occur due to 2017 HPV vaccination coverage compared with an optimal coverage of 99.5%. By multiplying those excess cases by the average cost of treatment, we determined the excess cost due to current HPV vaccination coverage.

resultsWith current vaccination coverage in California, the 20-year-old cohort is at risk for an excess 1352 cancer cases that could be prevented with a projected optimal vaccination coverage of 99.5%. The excess cost of treatment for those cancer cases would be US $52.2 million. Male oropharyngeal cancer accounts for the greatest projected cost burden US $21.3 million followed by cervical cancer US $16.1 million.

conclusionsIncreased HPV vaccination coverage in California is needed to reduce economic and health burdens associated with cancers caused by HPV infection.

Indexed as

CaliforniaCohort StudiesCost-Benefit AnalysisFemaleHealth Care CostsHumansMaleNeoplasmsPapillomavirus InfectionsPapillomavirus VaccinesVaccination CoverageYoung AdultPapillomavirus Vaccines

Identifiers

PMID31295221
PMCPMC6748638
OpenAlexW2950828378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.