Evidence map›Paper›PMID 31295086›Full record

ArticleRadiation research2019

Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines.

Stephanie Thermozier, Xichen Zhang, Wen Hou, Renee Fisher, Michael W Epperly, Bing Liu, Ivet Bahar, Hong Wang, Joel S Greenberger

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stephanie ThermozierDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
Xichen ZhangDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
Wen HouDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
Renee FisherDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
Michael W EpperlyDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
Bing LiuDepartment of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Ivet BaharDepartment of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Hong WangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Joel S GreenbergerDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania 15213.
UPMC Hillman Cancer Center · USUniversity of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Training and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GREENBERGER, JOEL S · 2005 to 2019
$44.4M
LR-IL-22 for Mitigation and Management of Radiation InjuriesU01AI172885 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOEL S GREENBERGER · 2023 to 2026
$2.4M
NCI NIH HHS P30 CA047904NIAID NIH HHS U01 AI172885NIAID NIH HHS U19 AI068021
6 · The paper itself

Abstract

Serpins are a group of serine-proteases involved in multiple signal transduction pathways in mammalian cells. In particular, Serpinb3a is involved in the lysosomal necrosis cell death pathway with components that overlap with radiation-induced apoptosis. We investigated the radiation response of Serpinb3a

Indexed as

Radiation ToleranceAnimalsApoptosisCell LineCell MovementGene DeletionHematopoiesisHematopoietic Stem CellsInterleukin-3Mesenchymal Stem CellsMiceRNA, MessengerSerpinsInterleukin-3RNA, MessengerSerpinb3b protein, mouseSerpins

Identifiers

PMID31295086
PMCPMC6759811
OpenAlexW2957184087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.