Evidence map›Paper›PMID 31294921›Full record

ArticleHuman brain mapping2019

Longitudinal increases in structural connectome segregation and functional connectome integration are associated with better recovery after mild TBI.

Amy F Kuceyeski, Keith W Jamison, Julia P Owen, Ashish Raj, Pratik Mukherjee

Abstract readComparative Study
In one paragraph

Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  11. Structure-function coupling in highly sampled individual brains.Cerebral cortex (New York, N.Y. : 1991) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy F KuceyeskiDepartment of Radiology, Weill Cornell Medicine, New York, New York.ORCID 0000-0002-5050-8342
Keith W JamisonDepartment of Radiology, Weill Cornell Medicine, New York, New York.
Julia P OwenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Ashish RajDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Pratik MukherjeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Predictive model of spread of Parkinson's pathology using network diffusionR01NS092802 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUPTA, AJAY, RAJ, ASHISH · 2016 to 2020
$2.8M
Multi-Modal Imaging of the Mechanisms Underlying Impaired Executive Attention After Traumatic Brain InjuryR01NS102646 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KUCEYESKI, AMY FRANCES, SHAH, SUDHIN · 2018 to 2022
$2.8M
Macrostructural and Microstructural Imaging Biomarkers of Traumatic Brain InjuryR01NS060776 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MUKHERJEE, PRATIK · 2009 to 2012
$1.8M
Multimodal modeling framework for fusing structural and functional connectome dataR01EB022717 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI NAGARAJAN, SRIKANTAN S., RAJ, ASHISH · 2016 to 2018
$1.6M
Quantifying the role of the connectome in resiliency to multiple sclerosisR21NS104634 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KUCEYESKI, AMY FRANCES · 2017 to 2018
$466k
Anna-Maria and Stephen Kellen Foundation Junior Faculty FellowshipGE HealthcareNIBIB NIH HHS R01 EB022717NINDS NIH HHS R01 NS060776NINDS NIH HHS R01 NS092802NINDS NIH HHS R01NS092802NINDS NIH HHS R01 NS102646NINDS NIH HHS R01 NS102646-01A1NINDS NIH HHS R21 NS104634NINDS NIH HHS R21 NS104634-01NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Traumatic brain injury damages white matter pathways that connect brain regions, disrupting transmission of electrochemical signals and causing cognitive and emotional dysfunction. Connectome-level mechanisms for how the brain compensates for injury have not been fully characterized. Here, we collected serial MRI-based structural and functional connectome metrics and neuropsychological scores in 26 mild traumatic brain injury subjects (29.4 ± 8.0 years, 20 males) at 1 and 6 months postinjury. We quantified the relationship between functional and structural connectomes using network diffusion (ND) model propagation time, a measure that can be interpreted as how much of the structural connectome is being utilized for the spread of functional activation, as captured via the functional connectome. Overall cognition showed significant improvement from 1 to 6 months (t

Indexed as

ConnectomeAdultAttentionBrain Injuries, TraumaticCase-Control StudiesCognition DisordersConvalescenceDiffusion Tensor ImagingFemaleFollow-Up StudiesHumansLearning DisabilitiesMagnetic Resonance ImagingMaleMemory DisordersModels, Neurologicalconnectomediffusion MRIimaging methodologyresting state connectivitytractographytraumatic brain injury

Identifiers

PMID31294921
PMCPMC6865536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.