Evidence map›Paper›PMID 31294886›Full record

ArticleProteins2020

A deep dense inception network for protein beta-turn prediction.

Chao Fang, Yi Shang, Dong Xu

Abstract read
In one paragraph

Article in Proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. A Perspective on the (Rise and Fall of) Protein β-Turns.International journal of molecular sciences · 2022
    Review
  5. PYTHIA: Deep Learning Approach for Local Protein Conformation Prediction.International journal of molecular sciences · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chao FangDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Yi ShangDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Dong XuDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.ORCID 0000-0002-4809-0514

Funding

Development of MUFOLD for Building High-Accuracy Protein Structure ModelsR01GM100701 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI XU, DONG · 2012 to 2016
$1.4M
NIGMS NIH HHS GM100701NIGMS NIH HHS R01 GM100701
6 · The paper itself

Abstract

Beta-turn prediction is useful in protein function studies and experimental design. Although recent approaches using machine-learning techniques such as support vector machine (SVM), neural networks, and K nearest neighbor have achieved good results for beta-turn prediction, there is still significant room for improvement. As previous predictors utilized features in a sliding window of 4-20 residues to capture interactions among sequentially neighboring residues, such feature engineering may result in incomplete or biased features and neglect interactions among long-range residues. Deep neural networks provide a new opportunity to address these issues. Here, we proposed a deep dense inception network (DeepDIN) for beta-turn prediction, which takes advantage of the state-of-the-art deep neural network design of dense networks and inception networks. A test on a recent BT6376 benchmark data set shows that DeepDIN outperformed the previous best tool BetaTPred3 significantly in both the overall prediction accuracy and the nine-type beta-turn classification accuracy. A tool, called MUFold-BetaTurn, was developed, which is the first beta-turn prediction tool utilizing deep neural networks. The tool can be downloaded at http://dslsrv8.cs.missouri.edu/~cf797/MUFoldBetaTurn/download.html.

Indexed as

Protein Conformation, beta-StrandAnimalsDatabases, ProteinHumansMachine LearningModels, MolecularNeural Networks, ComputerProtein FoldingProteinsSoftwareProteinsdeep learningdeep neural networkdense networkinception networkprotein beta turnprotein structure prediction

Identifiers

PMID31294886
PMCPMC6914211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.