Evidence map›Paper›PMID 31294817›Full record

ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2020

Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.

Jingchun Chen, Anu Loukola, Nathan A Gillespie, Roseann Peterson, Peilin Jia, Brien Riley, Hermine Maes, Daniella M Dick, Kenneth S Kendler, M Imad Damaj and 36 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 6 countries.

Jingchun ChenNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV.
Anu LoukolaDepartment of Public Health, University of Helsinki, Helsinki, FI, Finland.
Nathan A GillespieVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA.
Roseann PetersonVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA.
Peilin JiaSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX.
Brien RileyVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA.
Hermine MaesVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA.
Daniella M DickDepartment of Psychology, Virginia Commonwealth University, Richmond, VA.
Kenneth S KendlerVirginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA.
M Imad DamajDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA.
Michael F MilesDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA.
Zhongming ZhaoSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX.
Ming D LiState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jacqueline M VinkNetherlands Twin Register, Department of Biological Psychology, VU University, the Netherlands.
Camelia C MinicaNetherlands Twin Register, Department of Biological Psychology, VU University, the Netherlands.
Gonneke WillemsenNetherlands Twin Register, Department of Biological Psychology, VU University, the Netherlands.
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, VU University, the Netherlands.
Beenish QaiserDepartment of Public Health, University of Helsinki, Helsinki, FI, Finland.
Pamela A F MaddenDepartment of Psychiatry, Washington University, St. Louis, MO.
Tellervo KorhonenDepartment of Public Health, University of Helsinki, Helsinki, FI, Finland.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki, Finland.
Jenni HällforsInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Joel GelernterDepartment of Psychiatry, Yale University, New Haven, CT.
Henry R KranzlerDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA.
Richard ShervaSection of Biomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston, MA.
Lindsay FarrerSection of Biomedical Genetics, Department of Medicine, Boston University School of Medicine, Boston, MA.
Brion MaherDepartment of Mental Health, Johns Hopkins University, Baltimore, MD.
Michael VanyukovDepartment of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA.
Michelle TaylorMRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS, UK.
Jenifer J WareMRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS, UK.
Marcus R MunafòMRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, BS, UK.
Sharon M LutzDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
John E HokansonDepartment of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO.
Fangyi GuGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD.
Maria T LandiGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD.
Neil E CaporasoGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD.
Dana B HancockBehavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC.
Nathan C GaddisResearch Computing Division, RTI International, Research Triangle Park, NC.
Timothy B BakerCenter for Tobacco Research and Intervention, University of Wisconsin, Madison, WI.
Laura J BierutDepartment of Psychiatry, Washington University, St. Louis, MO.
Eric O JohnsonBehavioral Health and Criminal Justice Division, RTI International, Research Triangle Park, NC.
Meghan ChenowethCentre for Addiction and Mental Health, and Departments of Pharmacology and Toxicology, and Psychiatry, University of Toronto, Toronto, Canada.
Caryn LermanCenter for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA.
Rachel TyndaleCentre for Addiction and Mental Health, and Departments of Pharmacology and Toxicology, and Psychiatry, University of Toronto, Toronto, Canada.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, FI, Finland.
Xiangning ChenNevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV.
Virginia Commonwealth University · USUniversity of Helsinki · FIAmsterdam Neuroscience · NLRTI International · USUnited States Department of Health and Human Services · USUniversity of Bristol · GBBoston University · USCentre for Addiction and Mental Health · CAThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Nevada, Las Vegas · USUniversity of Pennsylvania · USWashington University in St. Louis · USFinnish Institute for Health and Welfare · FIFirst Affiliated Hospital Zhejiang University · CNJohns Hopkins University · USRadboud University Nijmegen · NLUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Genome Analysis and Sequencing Pipeline (GASP)P20GM121325 · NIGMS · UNIVERSITY OF NEVADA LAS VEGAS · PI LIU, QIAN · 2018 to 2022
$11.5M
Genes and molecular pathways in nicotine dependence and withdrawalR01DA032246 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DAMAJ, M. IMAD, MILES, MICHAEL F · 2013 to 2017
$1.7M
Utilizing Interaction to Identify Novel Genetic Factors for Nicotine DependenceR01DA035825 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI HANCOCK, DANA B · 2013 to 2015
$1.5M
Leveraging sources of heterogeneity to delineate the genetic architecture of major depressive disorderK01MH113848 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI PETERSON, ROSEANN ELIZABETH · 2018 to 2020
$546k
Medical Research Council MC_UU_00011/7NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA032246NIDA NIH HHS R01 DA035825NIGMS NIH HHS P20 GM121325NIMH NIH HHS K01 MH113848
6 · The paper itself

Abstract

introductionFTND (Fagerstrӧm test for nicotine dependence) and TTFC (time to smoke first cigarette in the morning) are common measures of nicotine dependence (ND). However, genome-wide meta-analysis for these phenotypes has not been reported.

methodsGenome-wide meta-analyses for FTND (N = 19,431) and TTFC (N = 18,567) phenotypes were conducted for adult smokers of European ancestry from 14 independent cohorts.

resultsWe found that SORBS2 on 4q35 (p = 4.05 × 10-8), BG182718 on 11q22 (p = 1.02 × 10-8), and AA333164 on 14q21 (p = 4.11 × 10-9) were associated with TTFC phenotype. We attempted replication of leading candidates with independent samples (FTND, N = 7010 and TTFC, N = 10 061), however, due to limited power of the replication samples, the replication of these new loci did not reach significance. In gene-based analyses, COPB2 was found associated with FTND phenotype, and TFCP2L1, RELN, and INO80C were associated with TTFC phenotype. In pathway and network analyses, we found that the interconnected interactions among the endocytosis, regulation of actin cytoskeleton, axon guidance, MAPK signaling, and chemokine signaling pathways were involved in ND.

conclusionsOur analyses identified several promising candidates for both FTND and TTFC phenotypes, and further verification of these candidates was necessary. Candidates supported by both FTND and TTFC (CHRNA4, THSD7B, RBFOX1, and ZNF804A) were associated with addiction to alcohol, cocaine, and heroin, and were associated with autism and schizophrenia. We also identified novel pathways involved in cigarette smoking. The pathway interactions highlighted the importance of receptor recycling and internalization in ND. IMPLICATIONS: Understanding the genetic architecture of cigarette smoking and ND is critical to develop effective prevention and treatment. Our study identified novel candidates and biological pathways involved in FTND and TTFC phenotypes, and this will facilitate further investigation of these candidates and pathways.

Indexed as

Genetic MarkersGenome, HumanGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideCigarette SmokingCohort StudiesGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMeta-Analysis as TopicReelin ProteinTobacco Use DisorderUnited StatesGenetic MarkersReelin ProteinRELN protein, human

Identifiers

PMID31294817
PMCPMC7249921
OpenAlexW2959259299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.