Evidence map›Paper›PMID 31294724›Full record

ArticleJournal of the Canadian Association of Gastroenterology2019

Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS).

Paul Moayyedi, Christopher N Andrews, Glenda MacQueen, Christina Korownyk, Megan Marsiglio, Lesley Graff, Brent Kvern, Adriana Lazarescu, Louis Liu, William G Paterson and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the Canadian Association of Gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 7 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 7 syntheses or guidelines pooled it, 190 citations in OpenAlex.

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  3. Effectiveness of diet, psychological, and exercise therapies for the management of bile acid diarrhoea in adults: A systematic review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Paul MoayyediDivision of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
Christopher N AndrewsDivision of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.
Glenda MacQueenDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Christina KorownykDepartment of Family Medicine, University of Alberta, Edmonton, Alberta, Canada.
Megan MarsiglioUnaffliated.
Lesley GraffDepartment of Clinical Health Psychology, University of Manitoba, Winnipeg, Manitoba, Canada.
Brent KvernDepartment of Family Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Adriana LazarescuDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.
Louis LiuDivision of Gastroenterology, University of Toronto, Toronto, Ontario, Canada.
William G PatersonDivision of Gastroenterology, Queen's University, Kingston, Ontario, Canada.
Sacha SidaniDivision of Gastroenterology, McMaster University, Hamilton, Ontario, Canada.
Stephen VannerDivision of Gastroenterology, Queen's University, Kingston, Ontario, Canada.
McMaster University · CAQueen's University · CAUniversity of Alberta · CAUniversity of Calgary · CAUniversity of Manitoba · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsIrritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders, affecting about 10% of the general population globally. The aim of this consensus was to develop guidelines for the management of IBS.

methodsA systematic literature search identified studies on the management of IBS. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. Statements were developed through an iterative online platform and then finalized and voted on by a multidisciplinary group of clinicians and a patient.

resultsConsensus was reached on 28 of 31 statements. Irritable bowel syndrome is diagnosed based on symptoms; serological testing is suggested to exclude celiac disease, but routine testing for C-reactive protein (CRP), fecal calprotectin or food allergies is not recommended. A trial of a low fermentable oligosaccharides, disaccharides, monosaccharides, polyols (FODMAP) diet is suggested, while a gluten-free diet is not. Psyllium, but not wheat bran, supplementation may help reduce symptoms. Alternative therapies such as peppermint oil and probiotics are suggested, while herbal therapies and acupuncture are not. Cognitive behavioural therapy and hypnotherapy are suggested psychological therapies. Among the suggested or recommended pharmacological therapies are antispasmodics, certain antidepressants, eluxadoline, lubiprostone, and linaclotide. Loperamide, cholestyramine and osmotic laxatives are not recommended for overall IBS symptoms. The nature of the IBS symptoms (diarrhea-predominant or constipation-predominant) should be considered in the choice of pharmacological treatments.

conclusionsPatients with IBS may benefit from a multipronged, individualized approach to treatment, including dietary modifications, psychological and pharmacological therapies.

Indexed as

Clinical practice guidelinesConstipationDiarrheaIrritable bowel syndrome

Identifiers

PMID31294724
PMCPMC6507291
OpenAlexW2909181645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.