Evidence map›Paper›PMID 31294688›Full record

ArticleeLife2019

Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters.

Nikolai Petkau, Harun Budak, Xunlei Zhou, Henrik Oster, Gregor Eichele

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  15. The molecular clockwork of mammalian cells.Seminars in cell & developmental biology · 2022
    Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nikolai PetkauDepartment of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0001-9168-3473
Harun BudakDepartment of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-7371-8959
Xunlei ZhouDepartment of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-9635-7068
Henrik OsterDepartment of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-1414-7068
Gregor EicheleDepartment of Genes and Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.ORCID 0000-0002-2863-9127
Max Planck Institute for Biophysical Chemistry · DE

Funding

Max-Planck-Gesellschaft Open-access fundingVolkswagen Foundation Lichtenberg Fellowship
6 · The paper itself

Abstract

Many physiological processes exhibit circadian rhythms driven by cellular clocks composed of interlinked activating and repressing elements. To investigate temporal regulation in this molecular oscillator, we combined mouse genetic approaches and analyses of interactions of key circadian proteins with each other and with clock gene promoters. We show that transcriptional activators control BRD4-PTEFb recruitment to

Indexed as

AnimalsARNTL Transcription FactorsBasic-Leucine Zipper Transcription FactorsBromodomain Containing ProteinsCircadian ClocksCircadian RhythmCLOCK ProteinsE-Box ElementsLysine Acetyltransferase 5MiceNuclear ProteinsPromoter Regions, GeneticProtein BindingTrans-ActivatorsTranscriptional ActivationTranscription FactorsARNTL Transcription FactorsBasic-Leucine Zipper Transcription FactorsBmal1 protein, mouseBrd4 protein, mouseBromodomain Containing ProteinsCLOCK ProteinsKat5 protein, mouseLysine Acetyltransferase 5Nuclear ProteinsTrans-ActivatorsTranscription Factorsacetylationchromosomescircadian rhythmgene expressionmouseneurosciencetranscription factors

Identifiers

PMID31294688
PMCPMC6650244
OpenAlexW2960853913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.