Evidence map›Paper›PMID 31294229›Full record

ReviewAIMS microbiology2018

An overview of the antimicrobial resistance mechanisms of bacteria.

Wanda C Reygaert

Abstract readReview
In one paragraph

Review in AIMS microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 712 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
712citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

712 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Public health challenges · 2026
    Review
  7. Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026
    Review
  8. Article
  9. Antimicrobial Resistance Gene Profiles inPathogens (Basel, Switzerland) · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Purification of Alkaloids fromMolecules (Basel, Switzerland) · 2026
    Article
  16. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Review

652 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Wanda C ReygaertDepartment of Biomedical Sciences, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to antimicrobial agents has become a major source of morbidity and mortality worldwide. When antibiotics were first introduced in the 1900's, it was thought that we had won the war against microorganisms. It was soon discovered however, that the microorganisms were capable of developing resistance to any of the drugs that were used. Apparently most pathogenic microorganisms have the capability of developing resistance to at least some antimicrobial agents. The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug. These mechanisms may be native to the microorganisms, or acquired from other microorganisms. Understanding more about these mechanisms should hopefully lead to better treatment options for infective diseases, and development of antimicrobial drugs that can withstand the microorganisms attempts to become resistant.

Indexed as

antimicrobial resistanceCREESBLMRSAβ-lactamase

Identifiers

PMID31294229
PMCPMC6604941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.