ArticleHeliyon2019
Expression of precipitating factors of pruritus found in humans in an imiquimod-induced psoriasis mouse model.
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Evaluation ofMediators of inflammation · 2024Article
- Inhibitory Effect of Evodiamine on Psoriasis Lesions and Itching in Mice.Clinical, cosmetic and investigational dermatology · 2024Article
- Molecular Mechanisms of Neurogenic Inflammation of the Skin.International journal of molecular sciences · 2023Review
- Effects of Qingre Huoxue Jiedu Formula on Nerve Growth Factor-Induced Psoriasis.Chinese journal of integrative medicine · 2022Article
- Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?International journal of molecular sciences · 2021Review
- Nintedanib ameliorates animal model of dermatitis.Scientific reports · 2020Article
- 2-deoxy-d-glucose Ameliorates Animal Models of Dermatitis.Biomedicines · 2020Article
- Raepenol™ Cream, a Complex of Natural Compounds, Promotes Wound Healing and Relieves PruritusIn vivo (Athens, Greece)Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo use a mouse model of imiquimod-induced psoriasis to investigate the relationship between pruritus and mast cells, nerve growth factor (NGF) and endogenous pruritogenic peptides, which are highly expressed in the skin of psoriasis patients. MAIN
methodsWe developed a mouse model of imiquimod-induced psoriasis and measured the frequency and duration of the model animals' self-scratching behavior using the SCLABA KEY
findingsTopical application of imiquimod increased the Psoriasis Area and Severity Index score as well as the frequency and duration of self-scratching. Regarding internal factors, increases in mast cells number and mRNA expression of NGF and endogenous pruritogenic peptide precursor were confirmed. SIGNIFICANCE: Self-scratching behavior is accompanied by increased number of mast cells and expression of NGF and endogenous pruritogenic peptides in our imiquimod-induced psoriasis model. The expression of these factors was consistent with the features in patients with pruritic psoriasis, suggesting that our model reflects at least some of the precipitating factors of pruritus found in humans.
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