Evidence map›Paper›PMID 31294051›Full record

ArticleData in brief2019

Analyses of rRNA gene chromatin in cell cycle arrested

Audrey Paillé, Romain Charton, Alexia Muguet, Joachim Griesenbeck, Michael J Smerdon, Antonio Conconi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Audrey PailléDépartement de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Romain ChartonDépartement de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Alexia MuguetDépartement de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Joachim GriesenbeckInstitut für Biochemie, Genetik und Mikrobiologie, Universität Regensburg, 93053 Regensburg, Germany.
Michael J SmerdonBiochemistry and Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164-7520, United States.
Antonio ConconiDépartement de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Université de Sherbrooke · CAUniversity of Regensburg · DEWashington State University · US

Funding

Repair of Carcinogen Damaged DNA in Human ChromatinR37ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J · 2001 to 2010
$4.0M
REPAIR OF CARCINOGEN-DAMAGED DNA IN HUMAN CHROMATINR01ES002614 · NIEHS · WASHINGTON STATE UNIVERSITY · PI SMERDON, MICHAEL J, WYRICK, JOHN J · 1985 to 2015
$2.5M
NIEHS NIH HHS R01 ES002614NIEHS NIH HHS R37 ES002614
6 · The paper itself

Abstract

The existence of two chromatin structures in the rDNA locus was previously demonstrated for a large variety of organisms, ranging from yeast to human. In yeast there are about 150-200 rRNA genes organized in tandem repeats. Almost half of them are transcribed and largely depleted of nucleosomes (active/open), the other half is not transcribed and is assembled in regular arrays of nucleosomes (inactive/closed). It is proposed that RNA polymerase-I (RNAPI) transcription-elongation removes nucleosomes from closed rRNA genes (opening), and that soon after DNA replication there is deposition of nucleosomes on the open rRNA genes (closing). In G1 arrested cells, nearly all rRNA genes are depleted of nucleosomes, but most of them are not transcribed (inactive/open). In relation to the research article by

Indexed as

Alpha-factorChromatinHydroxyureaPsoralen crosslinkingRNA polymerase IrRNA genes

Identifiers

PMID31294051
PMCPMC6595284
OpenAlexW2947064817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.