Evidence map›Paper›PMID 31294022›Full record

ArticleFrontiers in cell and developmental biology2019

DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces.

Navjot Kaur Gill, Chau Ly, Paul H Kim, Cosmo A Saunders, Loren G Fong, Stephen G Young, G W Gant Luxton, Amy C Rowat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Decreased mechanotransduction prevents nuclear collapse in aProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Review
  9. Article
  10. Novel advanced patient-derivedFrontiers in neurology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Navjot Kaur GillDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
Chau LyDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.
Paul H KimDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Cosmo A SaundersDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, United States.
Loren G FongDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Stephen G YoungDepartment of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
G W Gant LuxtonDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, United States.
Amy C RowatDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Development of a New Therapeutic Approach for Prelamin A DiseasesR01AG047192 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONG, LOREN GI · 2014 to 2018
$1.6M
TorsinA-mediated regulation of Cdc42 signaling and DYT1 dystoniaR01GM129374 · NIGMS · UNIVERSITY OF MINNESOTA · PI LUXTON, GEORGE WILLIAM GANT · 2018 to 2021
$1.2M
NIA NIH HHS R01 AG047192NIGMS NIH HHS R01 GM129374
6 · The paper itself

Abstract

DYT1 dystonia is a neurological movement disorder that is caused by a loss-of-function mutation in the

Indexed as

cell mechanical propertieslaminsLINC complexmechanotypenuclear envelopetorsinA

Identifiers

PMID31294022
PMCPMC6606767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.