Evidence map›Paper›PMID 31293969›Full record

ReviewFrontiers in oncology2019

The Minimal Residual Disease in Non-Hodgkin's Lymphomas: From the Laboratory to the Clinical Practice.

Sara Galimberti, Elisa Genuardi, Francesco Mazziotta, Lorenzo Iovino, Fortunato Morabito, Susanna Grassi, Elena Ciabatti, Francesca Guerrini, Mario Petrini

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Measurable Residual Disease.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  4. Review
  5. CD20-Targeted α-Radionuclides Synergize with Immune Checkpoint Inhibition to Treat Murine Lymphoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Article
  7. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Liquid Biopsy in B and T Cell Lymphomas: From Bench to Bedside.International journal of molecular sciences · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Exosome-Based Treatment for Atherosclerosis.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Sara GalimbertiSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Elisa GenuardiDepartment of Molecular Biotechnologies and Health Sciences, University of Torino, Turin, Italy.
Francesco MazziottaSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Lorenzo IovinoSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Fortunato MorabitoHematology Oncology Department, Augusta Victoria Hospital, East Jerusalem, Israel.
Susanna GrassiSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Elena CiabattiSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Francesca GuerriniSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Mario PetriniSection of Hematology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
University of Pisa · ITAugusta Victoria Hospital · ILUniversity of Siena · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minimal residual disease (MRD) in non-Hodgkin's lymphomas (NHLs) still represents matter of interest and debate: indeed, the new available treatments offer higher rates of complete responses and MRD negativity than in the past, with a positive impact on the long-term survival. Furthermore, the introduction of more sensitive and accurate molecular techniques, such as digital PCR (ddPCR) and the next generation sequencing techniques (NGS), increased the possibility of identifying molecular targets to be followed after therapy (such as rearrangement of immunoglobulins, fusion genes, or mutations). This review focused on how molecular biology can help to detect MRD in different types of NHLs and how MRD can change the clinical practice in 2019. In follicular lymphoma (FL), contamination of the grafts and molecular disease persistence after transplantation represent a negative prognostic factors. The combination of Rituximab or Obinutuzumab with Bendamustine seems to be the most effective way to clear MRD in FL patients receiving chemo-immunotherapy (further studies are in progress), and also

Indexed as

digital PCRlymphomaminimal residual diseaseMRDNGSNHLPCRQT-PCR

Identifiers

PMID31293969
PMCPMC6606710
OpenAlexW2953485549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.