ArticleAnnals of maxillofacial surgery
Management of Central Giant Cell Granulomas of the Jaws: An Unusual Case Report with Critical Appraisal of Existing Literature.
Article in Annals of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 43 citations in OpenAlex.
- Digitally Planned Reconstruction of a Case of Mandibular Central Giant Cell Granuloma in a Young Female: A Case Report.Journal of dentistry (Shiraz, Iran) · 2026Article
- Unveiling the mandibular mystery: a case of central giant cell granuloma in posterior mandibular region-a case report.Journal of medical case reports · 2025Article
- Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism-Radiological and Clinical Pitfalls and Dilemmas.Diagnostics (Basel, Switzerland) · 2025Article
- The Occurrence of Mandible Brown Tumor Mimicking Central Giant Cell Granuloma in a Case Suspicious of Primary Hyperparathyroidism-Troublesome Diagnostic Dilemmas.Diagnostics (Basel, Switzerland) · 2025Article
- Successful endoscopic resection of a rare extension of peripheral giant cell granuloma into the infratemporal fossa via the maxillary sinus: A case report study.International journal of surgery case reports · 2024Article
- Evaluating Treatment Modalities for Reducing Recurrence in Central Giant Cell Granuloma: A Narrative Review.Dentistry journal · 2024Review
- Imaging approach for jaw and maxillofacial bone tumors with updates from the 2022 World Health Organization classification.World journal of radiology · 2024Review
- Review
- Central giant cell granuloma in the posterior region of mandible mimicking a fibro-osseous lesion and hemangioma: a case report.Journal of medical case reports · 2024Article
- Successful Combined Treatment Approach for Central Giant Cell Granuloma: A Case Study of Surgery Following Intralesional Steroid Injection.World journal of plastic surgery · 2024Article
- The notch of the mandible: what do different fields call it?Anatomy & cell biology · 2023Article
- Aggressive giant cell lesion of mandible-confusing to common: true neoplasm versus reactive lesion.BMJ case reports · 2023Article
- Osteosarcoma of the mandible: A case with a clinical appearance similar to benign lesions.Clinical case reports · 2023Article
- Scalloped border as a possible diagnostic aid for differentiating jaw lesions: A pictorial essay.Imaging science in dentistry · 2022Article
- Cone-beam computed tomographic imaging of central giant cell granuloma: A comprehensive review.Imaging science in dentistry · 2022Review
- Mechanisms of acute hypercalcemia in pediatric patients following the interruption of Denosumab.Journal of endocrinological investigation · 2022Article
- Worsening Lower Jaw Swelling and Pain in a Teenager: Differential Diagnosis and Management.Cureus · 2021Article
- A Unique Case of Aggressive Central Giant Cell Granuloma in a 10-Year-Old Boy With 16p13.11 Microdeletion Syndrome.Journal of investigative medicine high impact case reportsArticle
- Rebound Hypercalcemia in a 14-Year-Old After Denosumab Therapy for Giant Cell Granuloma of the Mandible.AACE endocrinology and diabetesArticle
- Central giant cell granuloma of the mandible: A case report with review of literature.National journal of maxillofacial surgeryArticle
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Authors and funding
1 author.
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Abstract
Central giant cell granuloma (CGCG) is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindle-shaped mesenchymal stromal cells, scattered throughout the fibrovascular connective tissue stroma containing areas of hemorrhage. A rapid diagnostic assessment, together with an adequate histopathologic verification, is essential to improve the management and the prognosis of this locally destructive lesion. A rare case of a large destructive CGCG involving the entire right angle of mandible, causing extensive bony resorption, and buccal, medial as well as inferior border cortical expansion with multiple perforations, in a young child is presented. It was treated successfully by enucleation and aggressive curettage followed by peripheral ostectomy preserving the continuity of the mandible. Two adjunctive measures were employed; first, chemical cauterization of the residual bony walls to prevent possible recurrence, for which this tumor is notorious, and second, placement of fresh autologous platelet-rich fibrin within the bony defect to hasten bone fill and reossification, thus obviating the need for a bone graft.
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