Evidence map›Paper›PMID 31293815›Full record

ArticleTranslational vision science & technology2019

First Clinical Application of Low-Cost OCT.

Ge Song, Kengyeh K Chu, Sanghoon Kim, Michael Crose, Brian Cox, Evan T Jelly, J Niklas Ulrich, Adam Wax

Abstract read
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. The march to harmonized imaging standards for retinal imaging.Progress in retinal and eye research · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ge SongDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Kengyeh K ChuDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Sanghoon KimDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Michael CroseDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Brian CoxDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Evan T JellyDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
J Niklas UlrichKittner Eye Center, University of North Carolina, Chapel Hill, NC, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.

Funding

Advanced a/LCI systems for improved clinical utilityR01CA210544 · NCI · DUKE UNIVERSITY · PI SHAHEEN, NICHOLAS J, WAX, ADAM · 2017 to 2021
$2.7M
NCI NIH HHS R01 CA210544
6 · The paper itself

Abstract

purposeWe present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study.

methodsA spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using both the low-cost OCT and a Heidelberg Engineering Spectralis OCT. Contrast-to-noise ratio (CNR) was measured from resulting images to determine system performance.

resultsThe low-cost OCT system was successfully applied to clinical imaging of the retina. The system offers an axial resolution of 8.0 μm, a lateral resolution of 19.6 μm, and an imaging depth of 2.7 mm for a 6.6-mm field of view in the X and Y directions. Total cost is $5037, a significant size reduction compared to current commercial higher performance systems. Mean CNR value of low-cost OCT images is only 5.6% lower compared to the Heidelberg Spectralis.

conclusionsThe images captured with the low-cost OCT were of adequate resolution and allowed for clinical diagnostics. It offers comparable performance as a retinal screening tool at a fraction of the cost of current commercial systems. TRANSLATIONAL RELEVANCE: Low-cost OCT has the potential to increase access to retinal imaging.

Indexed as

diagnostic imagingoptical coherence tomographypoint of care

Identifiers

PMID31293815
PMCPMC6602122

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.