ReviewClinical & translational immunology2019
A pathologic two-way street: how innate immunity impacts lung fibrosis and fibrosis impacts lung immunity.
Review in Clinical & translational immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Clinical Analysis of Relapse Risk in Immune-Checkpoint-Inhibitor-Related Pneumonitis.Journal of clinical medicine · 2026Article
- How the Fibrotic Lung Microenvironment Regulates Stem Cell Behavior: Immune Cues, Extracellular Matrix Remodeling, and Therapeutic Implications.Analytical cellular pathology (Amsterdam) · 2026Review
- Porcine respiratory disease complex induces pulmonary fibrosis related to the aberrant sphingolipid metabolism.International journal of experimental pathology · 2025Article
- The Importance of Lung Innate Immunity During Health and Disease.Pathogens (Basel, Switzerland) · 2025Review
- Targeting pleuro-alveolar junctions reverses lung fibrosis in mice.Nature communications · 2025Article
- Review
- An agent-based model of tissue maintenance and self-repair.American journal of physiology. Cell physiology · 2023Article
- microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis.JCI insight · 2023Article
- Stem cell-based therapy for pulmonary fibrosis.Stem cell research & therapy · 2022Review
- Bioactive fish collagen peptides weaken intestinal inflammation by orienting colonic macrophages phenotype through mannose receptor activation.European journal of nutrition · 2022Article
- Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities.American journal of respiratory and critical care medicine · 2022Article
- Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function.JCI insight · 2022Article
- Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities.Progress in retinal and eye research · 2021Review
- Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis.EMBO molecular medicine · 2020Article
- Epithelial Dysfunction in Lung Diseases: Effects of Amino Acids and Potential Mechanisms.Advances in experimental medicine and biology · 2020Review
- Genetic Risk Factors for Idiopathic Pulmonary Fibrosis: Insights into Immunopathogenesis.Journal of inflammation research · 2020Review
- Immunopathobiology of chronic lung disease.Clinical & translational immunology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Lung fibrosis is characterised by the accumulation of extracellular matrix within the lung and is secondary to both known and unknown aetiologies. This accumulation of scar tissue limits gas exchange causing respiratory insufficiency. The pathogenesis of lung fibrosis is poorly understood, but immunologic-based treatments have been largely ineffective. Despite this, accumulating evidence suggests that innate immune cells and receptors play important modulatory roles in the initiation and propagation of the disease. Paradoxically, while innate immune signalling may be important for the pathogenesis of fibrosis, there is also evidence to suggest that innate immune function against pathogens may be impaired, leading to dysregulated and/or impaired host defence. This review summarises the evidence for this pathologic two-way street, highlights new concepts of pathogenesis and recommends future directions for research emphasis.
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Registered trials
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