Evidence map›Paper›PMID 31293618›Full record

ArticleFrontiers in genetics2019

Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.

Gemma Amo, Manuel Martí, Jesús M García-Menaya, Concepción Cordobés, José A Cornejo-García, Natalia Blanca-López, Gabriela Canto, Inmaculada Doña, Miguel Blanca, María José Torres and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Marine drugs · 2020
    Article
  7. Genetic polymorphisms in vitamin D pathway influence 25(OH)D levels and are associated with atopy and asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
  8. The nuts and bolts of omics for the clinical allergist.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Gemma AmoUniversity Institute of Molecular Pathology Biomarkers, UEx, Cáceres, Spain.
Manuel MartíUniversity Institute of Molecular Pathology Biomarkers, UEx, Cáceres, Spain.
Jesús M García-MenayaAllergy Service, Badajoz University Hospital, Badajoz, Spain.
Concepción CordobésAllergy Service, Mérida Hospital, Badajoz, Spain.
José A Cornejo-GarcíaResearch Laboratory, IBIMA, Regional University Hospital of Málaga, UMA, Málaga, Spain.
Natalia Blanca-LópezAllergy Service, Infanta Leonor University Hospital, Madrid, Spain.
Gabriela CantoAllergy Service, Infanta Leonor University Hospital, Madrid, Spain.
Inmaculada DoñaAllergy Unit, IBIMA, Regional University Hospital of Málaga, UMA, Málaga, Spain.
Miguel BlancaAllergy Service, Infanta Leonor University Hospital, Madrid, Spain.
María José TorresAllergy Unit, IBIMA, Regional University Hospital of Málaga, UMA, Málaga, Spain.
José A G AgúndezUniversity Institute of Molecular Pathology Biomarkers, UEx, Cáceres, Spain.
Elena García-MartínUniversity Institute of Molecular Pathology Biomarkers, UEx, Cáceres, Spain.
Instituto de Salud Carlos III · ESCentro de Implantología Cirugía Oral y Maxilofacial · ESHospital Regional Universitario de Málaga · ESHospital Universitario Infanta Leonor · ESInstituto de Investigación Biomédica de Málaga · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of allergic diseases and drug hypersensitivity reactions (DHRs) during recent years is increasing. Both, allergic diseases and DHRs seem to be related to an interplay between environmental factors and genetic susceptibility. In recent years, a large effort in the elucidation of the genetic mechanisms involved in these disorders has been made, mostly based on case-control studies, and typically focusing on isolated SNPs. These studies provide a limited amount of information, which now can be greatly expanded by the complete coverage that Next Generation Sequencing techniques offer. In this study, we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including

Indexed as

allergic rhinitisasthmabeta-lactam antibioticdrugs hypersensitivity reactionshigh-affinity IgE receptor (FCεRI)Next-Generation Sequencing (NGS)NSAIDs (non-steroidal anti-inflammatory drugs)vitamin D

Identifiers

PMID31293618
PMCPMC6603231
OpenAlexW2956087117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.