Evidence map›Paper›PMID 31293562›Full record

ArticleFrontiers in microbiology2019

Analysis of the Relationship Between the Degree of Dysbiosis in Gut Microbiota and Prognosis at Different Stages of Primary Hepatocellular Carcinoma.

Jiajia Ni, Rong Huang, Huifang Zhou, Xiaoping Xu, Yang Li, Peihua Cao, Kebo Zhong, Mei Ge, Xiaoxia Chen, Baohua Hou and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 121 citations in OpenAlex.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Jiajia NiDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Rong HuangDepartment of Neonatal Surgery, Guangdong Women and Children Hospital, Guangzhou, China.
Huifang ZhouDepartment of Clinical Laboratory, First People's Hospital of Kashi, Kashgar, China.
Xiaoping XuDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Yang LiDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Peihua CaoDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Kebo ZhongDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Mei GeDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Xiaoxia ChenDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Baohua HouDepartment of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Min YuDepartment of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Baogang PengDepartment of Hepatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Qiao LiDepartment of Hepatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Peng ZhangDepartment of Organ Transplantation, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yi GaoDepartment of Hepatobiliary Surgery II, Guangdong Provincial Research Center of Artificial Organ and Tissue Engineering, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Zhujiang Hospital · CNSouthern Medical University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNGuangdong Academy of Medical Sciences · CNGuangdong General Hospital · CNGuangdong Province Women and Children Hospital · CNGuangzhou Medical University · CNKashi University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis is closely associated with primary hepatocellular carcinoma (HCC). Recent studies have evaluated the early diagnosis of primary HCC through analysis of gut microbiota dysbiosis. However, the relationship between the degree of dysbiosis and the prognosis of primary HCC remains unclear. Because primary HCC is accompanied by dysbiosis and dysbiosis usually increases the circulatory concentrations of endotoxin and other harmful bacterial substances, which further increases liver damage, we hypothesized that level of dysbiosis associated with primary HCC increases with the stage of cancer progression. To test this hypothesis, we introduced a more integrated index referred to as the degree of dysbiosis (

Indexed as

chronic liver diseasesdysbiosis degreegut microbiotaprimary hepatocellular carcinomaprognosis

Identifiers

PMID31293562
PMCPMC6603198
OpenAlexW2953449085

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.