Evidence map›Paper›PMID 31293546›Full record

ArticleFrontiers in microbiology2019

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A.

Anthony J Saviola, Cosima Zimmermann, Michael P Mariani, Sylvia A Signorelli, Diana L Gerrard, Joseph R Boyd, Darren J Wight, Guillaume Morissette, Annie Gravel, Isabelle Dubuc and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. Hematopoietic stem cells and betaherpesvirus latency.Frontiers in cellular and infection microbiology · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Evasion of the Host Immune Response by Betaherpesviruses.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Herpesvirus latency.The Journal of clinical investigation · 2020
    Review
  16. Article
  17. Herpesviral Latency-Common Themes.Pathogens (Basel, Switzerland) · 2020
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Anthony J SaviolaDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States.
Cosima ZimmermannInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Michael P MarianiDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States.
Sylvia A SignorelliDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States.
Diana L GerrardDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States.
Joseph R BoydDepartment of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, Burlington, VT, United States.
Darren J WightInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Guillaume MorissetteDepartment of Microbiology, Infectious Disease and Immunology, Université Laval and CHU de Quebec Research Center-Université Laval, Quebec, QC, Canada.
Annie GravelDepartment of Microbiology, Infectious Disease and Immunology, Université Laval and CHU de Quebec Research Center-Université Laval, Quebec, QC, Canada.
Isabelle DubucDepartment of Microbiology, Infectious Disease and Immunology, Université Laval and CHU de Quebec Research Center-Université Laval, Quebec, QC, Canada.
Louis FlamandDepartment of Microbiology, Infectious Disease and Immunology, Université Laval and CHU de Quebec Research Center-Université Laval, Quebec, QC, Canada.
Benedikt B KauferInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
Seth FrietzeDepartment of Biomedical and Health Sciences, University of Vermont, Burlington, VT, United States.
University of Vermont · USUniversité Laval · CAFreie Universität Berlin · DE

Funding

Integration and epigenetic regulation of the HHV-6 genomeR21AI121528 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FRIETZE, SETH E, KAUFER, BENEDIKT B. · 2016 to 2017
$400k
NIAID NIH HHS R21 AI121528
6 · The paper itself

Abstract

Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis. The HHV-6A/B genomes have been shown to be present in an integrated state in the telomeres of latently infected cells. In addition, integration of HHV-6A/B in germ cells has resulted in individuals harboring this inherited chromosomally integrated HHV-6A/B (iciHHV-6) in every cell of their body. Until now, the viral transcriptome and the epigenetic modifications that contribute to the silencing of the integrated virus genome remain elusive. In the current study, we used a patient-derived iciHHV-6A cell line to assess the global viral gene expression profile by RNA-seq, and the chromatin profiles by MNase-seq and ChIP-seq analyses. In addition, we investigated an

Indexed as

ChIP-seqHHV-6AiciHHV-6AlatencyMNase-seqnucleosomesRNA-seq

Identifiers

PMID31293546
PMCPMC6606781
OpenAlexW2955906059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.