ArticleFrontiers in neurology2019
Use of Cerebrospinal Fluid Biomarkers in Diagnosis and Monitoring of Rheumatoid Meningitis.
Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Focal Motor Seizures as a Manifestation of Rheumatoid Meningitis: From the National Multiple Sclerosis Society Case Conference Proceedings.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Rheumatoid Meningitis with Generalized Convulsions during Peficitinib Treatment, in Which Anti-cyclic Citrullinated Peptide Antibody in the Cerebrospinal Fluid Was Useful for Making a Diagnosis: A Review of the Literature and Previous Reports.Internal medicine (Tokyo, Japan) · 2025Review
- Cerebral rheumatoid vasculitis: an integrated analysis of case presentation, literature review, and prognostic stratification.Frontiers in immunology · 2025Review
- New-onset seizures: an unusual neurologic manifestation of rheumatoid arthritis.Oxford medical case reports · 2024Article
- Cerebrospinal Fluid Analysis in Rheumatological Diseases with Neuropsychiatric Complications and Manifestations: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- A Case of Rheumatoid Meningitis Diagnosed with FLAIR Images and Anti-cyclic Citrullinated Peptide Antibodies Levels.NMC case report journal · 2024Article
- Rheumatoid meningitis without a history of rheumatoid arthritis: a case report and literature review.Rheumatology international · 2023Review
- Non-infectious encephalopathy with recurrent stroke-like episodes: a case of rheumatoid meningitis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis.Biomedicines · 2022Article
- Ion Mobility Mass Spectrometry Reveals Rare Sialylated Glycosphingolipid Structures in Human Cerebrospinal Fluid.Molecules (Basel, Switzerland) · 2022Article
- Case Report: Rheumatoid meningitis with positive NMDAR antibody: A case treated with intravenous immunoglobulin.Frontiers in immunology · 2022Article
- Endothelial Dysfunction and Extra-Articular Neurological Manifestations in Rheumatoid Arthritis.Biomolecules · 2021Review
- Leptomeningitis in rheumatoid arthritis.European journal of rheumatology · 2021Review
- CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis.EBioMedicine · 2020Article
- Rheumatoid meningitis and infection in absence of rheumatoid arthritis history: review of 31 cases.Clinical rheumatology · 2020Review
- Correction to: Anti-cyclic citrullinated peptide antibody in the cerebrospinal fluid in patients with rheumatoid arthritis who have central nervous system involvement.Clinical rheumatology · 2020Article
- Anti-cyclic citrullinated peptide antibody in the cerebrospinal fluid in patients with rheumatoid arthritis who have central nervous system involvement.Clinical rheumatology · 2020Review
- Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review.Journal of clinical medicine · 2020Article
- Inflammatory Manifestations of Systemic Diseases in the Central Nervous System.Current treatment options in neurology · 2020Review
- Rheumatoid arthritis with pachymeningitis - a case presentation and review of the literature.Reumatologia · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid meningitis is a rare extra-articular manifestation of rheumatoid arthritis, often with non-specific symptoms. In most cases brain MRI shows a patchy lepto- and pachymeningeal enhancement, but the diagnosis currently relies on examination of a meningeal biopsy with presence of plasma cells and rheumatoid noduli. Presence of IgM rheumatic factor (RF) has been found in several cases and recently four cases have shown high titer anti-cyclic citrullinated peptide (anti-CCP) in CSF, suggesting this as a potential marker for rheumatoid meningitis. We present a 62 year-old woman with sero-positive (IgM RF and anti-CCP) rheumatoid arthritis, presenting with headache and gait impairment. Brain MRI revealed the classical patchy meningeal enhancement and the diagnosis of rheumatoid meningitis was confirmed by neuropathological examination of a meningeal biopsy. Analysis of the CSF revealed positive IgM RF (92.7 IU/mL) and strongly positive anti-CCP (19,600 IU/mL) and CXCL-13 (>500 ng/L). After treatment with high-dose steroid and Rituximab the clinical symptoms resolved. A 6 month follow-up analysis of CSF showed a dramatic decrease in all these markers with negative IgM RF and a decrease in both anti-CCP (64 IU/mL) and CXCL-13 (<10 ng/L). Our case further underlines the potential use of CSF anti-CCP and IgM RF in the diagnosis of RM and the use of these markers and CXCL-13 in evaluation of treatment response. A case review of 48 cases of rheumatoid meningitis published since 2010, including, symptoms, serum, and CSF findings, treatment, and outcome is provided.
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