ArticleFrontiers in psychiatry2019
Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations.
Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- A systematic review and meta analysis of open label placebo effects in chronic musculoskeletal pain.Scientific reports · 2025Pooled it
- Pooled it
- The role of expectations and tailored feedback on the open-label Placebo effect.Journal of health psychology · 2026Trial
- Experimental Approach to Inducing Anti-Histaminergic Placebo Effects: A Randomized Controlled Trial in Healthy Volunteers.Neuroimmunomodulation · 2026Trial
- Increasing the Effectiveness of a Physical Activity Smartphone Intervention With Positive Suggestions: Randomized Controlled Trial.Journal of medical Internet research · 2022Trial
- Lay perspectives of the open-label placebo rationale: a qualitative study of participants in an experimental trial.BMJ open · 2021Trial
- Nocebo Effects on Cowhage-evoked Itch: A Randomized Controlled Trial of Classical Conditioning and Observational Learning.Acta dermato-venereologica · 2021Trial
- Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial.Frontiers in medicine · 2024Article
- Can contagious itch be affected by positive and negative suggestions?Experimental dermatology · 2022Article
- Open-Label Placebo Effects on Psychological and Physical Well-Being: A Conceptual Replication Study.Clinical psychology in Europe · 2022Article
- [The effect of treatment expectations on pruritus and skin pain].Schmerz (Berlin, Germany) · 2022Review
- Induction and generalization of nocebo effects on itch.Experimental dermatology · 2022Article
- Bibliometric analysis of hotspots and frontiers in cancer-related fatigue among ovarian cancer survivors.PloS one · 2022Article
- Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch.Frontiers in psychology · 2021Article
- Open-Label Placebo Treatment for Acute Postoperative Pain (OLP-POP Study): Study Protocol of a Randomized Controlled Trial.Frontiers in medicine · 2021Article
- Emerging Therapeutic Options for Chronic Pruritus.American journal of clinical dermatology · 2020Review
- One step closer to alleviating uraemic pruritus.Nature reviews. Nephrology · 2020Article
- Information About the Optimism of a Placebo/Nocebo Provider and Placebo/Nocebo Side Effects.Frontiers in psychology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placebo and nocebo effects have been shown to influence subjective symptoms such as itch. These effects can be induced by influencing outcome expectations through, for example, combining the application of an inert substance (e.g., a cream) with verbal suggestions on the anticipated effects of this substance. Interestingly, placebo effects also occur when it is known that a treatment is inert (i.e., open-label placebo). However, no study to date has examined the efficacy of negative and positive verbal suggestions under similar open-label and closed-label (i.e., concealed placebo/nocebo) conditions in itch. A randomized controlled between-subjects study design was applied in which healthy volunteers (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.