Evidence map›Paper›PMID 31293444›Full record

ArticleFrontiers in physiology2019

Disuse Impairs the Mechanical Competence of Bone by Regulating the Characterizations of Mineralized Collagen Fibrils in Cortical Bone.

Peng-Fei Yang, Xiao-Tong Nie, Zhe Wang, Luban Hamdy Hameed Al-Qudsy, Li Ren, Hui-Yun Xu, Joern Rittweger, Peng Shang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. PeerJ · 2025
    Article
  2. Similarities Between Disuse and Age-Induced Bone Loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Review
  3. Review
  4. Review
  5. The regulation of RANKL by mechanical force.Journal of bone and mineral metabolism · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Peng-Fei YangKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Xiao-Tong NieKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Zhe WangKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Luban Hamdy Hameed Al-QudsyKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Li RenKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Hui-Yun XuKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Institute of Special Environmental Biophysics, Northwestern Polytechnical University, Xi'an, China.
Joern RittwegerDivision of Muscle & Bone Metabolism, Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany.
Peng ShangResearch & Development Institute, Northwestern Polytechnical University, Shenzhen, China.
Northwestern Polytechnical University · CNDeutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bones are made of complex material comprising organic components and mineral hydroxyapatite, both of which formulate the unique hierarchical structure of bone and its mechanical properties. Bones are capable of optimizing their structure and mechanical properties according to the mechanical environment. Mineral loss is a well-known consequence of skeleton disuse. By contrast, the response of the non-mineral phase of bone, i.e., the collagen network, during disuse remain largely unknown. In this study, a tail-suspension mice model was used to induce bone loss. Atomic force microscopy-based imaging and indentation approaches were adopted to investigate the influence of disuse on the morphology and

Indexed as

atomic force microscopybonecollagen fibrildisusemechanical properties

Identifiers

PMID31293444
PMCPMC6598106
OpenAlexW2950205778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.