ArticleFrontiers in aging neuroscience2019
Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Accuracy and Precision of the Subjective Visual Vertical According to Age in Adults With/Without Diabetes.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Quantifying calretinin-labeled afferent terminals in vestibular sensory epithelia of young and older gerbils.Neurobiology of aging · 2026Article
- Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.BMC genomics · 2026Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.The Journal of physiology · 2025Article
- Efficacy of the silicon based agent for age related decline in vestibular function.Scientific reports · 2025Article
- Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development.eLife · 2025Article
- Audiometry as a predictive proxy for balance dysfunction.Scientific reports · 2025Article
- Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells.Development (Cambridge, England) · 2024Article
- Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells.bioRxiv : the preprint server for biology · 2024Article
- TMC function, dysfunction, and restoration in mouse vestibular organs.Frontiers in neurology · 2024Article
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- Functional, Morphological and Molecular Changes Reveal the Mechanisms Associated with Age-Related Vestibular Loss.Biomolecules · 2023Article
- Cellular and Molecular Mechanisms of Vestibular Ageing.Journal of clinical medicine · 2023Review
- Peripheral vestibular loss in noise-exposed firefighters.Frontiers in integrative neuroscience · 2023Article
- Age-dependent structural reorganization of utricular ribbon synapses.Frontiers in cell and developmental biology · 2023Article
- Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice.Hearing research · 2022Article
- What Predictability for Animal Models of Peripheral Vestibular Disorders?Biomedicines · 2022Review
- Peripheral vestibular system: Age-related vestibular loss and associated deficits.Journal of otology · 2021Review
- Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes.Frontiers in neuroscience · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Age-related decline of inner ear function contributes to both hearing loss and balance disorders, which lead to impaired quality of life and falls that can result in injury and even death. The cellular mechanisms responsible for the ear's functional decline have been controversial, but hair cell loss has been considered the key cause for a long time. However, recent studies showed that in the cochlea, loss of inner hair cell (IHC) synapses precedes hair cell or neuronal loss, and this synaptopathy is an early step in the functional decline. Whether a similar process occurs in the vestibular organ, its timing and its relationship to organ dysfunction remained unknown. We compared the time course of age-related deterioration in vestibular and cochlear functions in mice as well as characterized the age-associated changes in their utricles at the histological level. We found that in the mouse, as in humans, age-related decline in vestibular evoked potentials (VsEPs) occurs later than hearing loss. As in the cochlea, deterioration of VsEPs correlates with the loss of utricular ribbon synapses but not hair cells or neuronal cell bodies. Furthermore, the age-related synaptic loss is restricted to calyceal innervations in the utricular extrastriolar region. Hence, our findings suggest that loss of extrastriolar calyceal synapses has a key role in age-related vestibular dysfunction (ARVD).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.