ArticleFrontiers in behavioral neuroscience2019
Open(G)PIAS: An Open-Source Solution for the Construction of a High-Precision Acoustic Startle Response Setup for Tinnitus Screening and Threshold Estimation in Rodents.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- A Single Dose of AC102 Reverts Tinnitus by Restoring Ribbon Synapses in Noise-Exposed Mongolian Gerbils.International journal of molecular sciences · 2025Article
- Tinnitus Generation and Behavioral Changes Caused by Chronic Stress: A Behavioral and Brain Study in a Rat Model.The Laryngoscope · 2025Article
- Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils.BMC neuroscience · 2024Article
- Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception.Brain : a journal of neurology · 2023Review
- A Custom Solution for Acoustic Startle Response Setup with Spike2-Based Data Acquisition Interface.Methods and protocols · 2023Article
- Preventive Effects of Ginkgo-Extract EGb 761Nutrients · 2022Article
- Circadian Sensitivity of Noise Trauma-Induced Hearing Loss and Tinnitus in Mongolian Gerbils.Frontiers in neuroscience · 2022Article
- Simulated transient hearing loss improves auditory sensitivity.Scientific reports · 2021Article
- Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength.Frontiers in behavioral neuroscience · 2021Article
- Automated classification of acoustic startle reflex waveforms in young CBA/CaJ mice using machine learning.Journal of neuroscience methods · 2020Article
- Animal Models of Tinnitus: A Review.Otolaryngologic clinics of North America · 2020Review
- Leveraging open hardware to alleviate the burden of COVID-19 on global health systems.PLoS biology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The modulation of the acoustic startle reflex (ASR) by a pre-stimulus called pre-pulse inhibition (PPI, for gap of silence pre-stimulus: GPIAS) is a versatile tool to, e.g., estimate hearing thresholds or identify subjective tinnitus percepts in rodents. A proper application of these paradigms depends on a reliable measurement of the ASR amplitudes and an exact stimulus presentation in terms of frequency and intensity. Here, we introduce a novel open-source solution for the construction of a low-cost ASR setup. The complete software for data acquisition and stimulus presentation is written in Python 3.6 and is provided as an Anaconda package. Furthermore, we provide a construction plan for the sensor system based on low-cost hardware components. Exemplary GPIAS data from two animal models (
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