ArticleFrontiers in neuroscience2019
Simultaneous Measurement of Neuronal Activity in the Pontine Micturition Center and Cystometry in Freely Moving Mice.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- in vivo Reprogramming of NG2 Glia Improves Bladder Function After Spinal Cord Injury.bioRxiv : the preprint server for biology · 2025Article
- Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Specific Control of Micturition.Research square · 2025Article
- SST neurons in the periaqueductal gray regulate urination and bladder function.Communications biology · 2025Article
- An innovative electrical neurostimulation approach to mimic reflexive urination control in spinal cord injury models.Scientific reports · 2024Article
- A wireless, battery-free device for electrical neuromodulation of bladder contractions.Materials today. Bio · 2024Article
- Article
- Neural circuit control of innate behaviors.Science China. Life sciences · 2022Review
- Ventrolateral Periaqueductal Gray Neurons Are Active During Urination.Frontiers in cellular neuroscience · 2022Article
- Neurophysiological control of urinary bladder storage and voiding-functional changes through development and pathology.Pediatric nephrology (Berlin, Germany) · 2021Review
- Social isolation uncovers a circuit underlying context-dependent territory-covering micturition.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Acyloxyacyl hydrolase regulates voiding activity.American journal of physiology. Renal physiology · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
- Monitoring Astrocytic CaFrontiers in cellular neuroscience · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the complex neural mechanisms controlling urinary bladder activity is an extremely important topic in both neuroscience and urology. Simultaneously recording of the bladder activity and neural activity in related brain regions will largely advance this field. However, such recording approach has long been restricted to anesthetized animals, whose bladder function and urodynamic properties are largely affected by anesthetics. In our recent report, we found that it is feasible to record bladder pressure (cystometry) and the related cortical neuron activity simultaneously in freely moving mice. Here, we aimed to demonstrate the use of this combined method in freely moving mice for recording the activity of the pontine micturition center (PMC), a more difficultly approachable small region deeply located in the brainstem and a more popularly studied hub for controlling bladder function. Interestingly, we found that the duration of urination events linearly correlated to the time course of neuronal activity in the PMC. We observed that the activities of PMC neurons highly correlated with spike-like increases in bladder pressure, reflecting bladder contractions. We also found that anesthesia evoked prominent changes in the dynamics of the Ca
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