Evidence map›Paper›PMID 31293376›Full record

ReviewFrontiers in neuroscience2019

Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers.

Kasper Katisko, Antti Cajanus, Titta Korhonen, Anne M Remes, Annakaisa Haapasalo, Eino Solje

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
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  6. Article
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  8. Review
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kasper KatiskoInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Antti CajanusInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Titta KorhonenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Anne M RemesInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Annakaisa HaapasaloA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Eino SoljeInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the current diagnostic criteria, early diagnostics of behavioral variant of frontotemporal dementia (bvFTD) has remained challenging. Patients with bvFTD often present with misleading psychiatric phenotype, and, on the other hand, impairment in memory functions have increasingly been reported. However, impaired episodic memory is currently considered as an exclusion criterion for bvFTD. Single biofluid-based or imaging biomarkers do not currently provide sufficient sensitivity or specificity for early bvFTD diagnosis at single-subject level, although studies have suggested improved accuracy with different biomarker combinations. In this mini review, we evaluate the core clinical features of early bvFTD and summarize the most potential imaging and fluid biomarkers for bvFTD diagnostics.

Indexed as

biomarkerC9orf72diagnosticsdifferential diagnosticsfrontotemporal dementiafrontotemporal lobar degenerationGRNneuroimaging

Identifiers

PMID31293376
PMCPMC6598427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.